About the Authors

Denise M. Smith

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations Division of Geriatric Medicine, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America, Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America, Institute for Translational Neuroscience, Saint Louis University, St. Louis, Missouri, United States of America

Michael L. Niehoff

Roles Investigation, Methodology, Writing – review & editing

Affiliations Division of Geriatric Medicine, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America, Veterans Affairs Medical Center, St. Louis, Missouri, United States of America

Karen Ling

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Ionis Pharmaceuticals, Carlsbad, California, United States of America

Paymaan Jafar-Nejad

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Ionis Pharmaceuticals, Carlsbad, California, United States of America

Frank Rigo

Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

Affiliation Ionis Pharmaceuticals, Carlsbad, California, United States of America

Susan A. Farr

Roles Investigation, Methodology, Supervision, Writing – review & editing

Affiliations Division of Geriatric Medicine, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America, Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America, Institute for Translational Neuroscience, Saint Louis University, St. Louis, Missouri, United States of America, Veterans Affairs Medical Center, St. Louis, Missouri, United States of America

Miles F. Wilkinson

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing

Affiliations Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, La Jolla, California, United States of America, Institute of Genomic Medicine, University of California San Diego, La Jolla, California, United States of America

Andrew D. Nguyen

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

andy.d.nguyen@health.slu.edu

Affiliations Division of Geriatric Medicine, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America, Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America, Institute for Translational Neuroscience, Saint Louis University, St. Louis, Missouri, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: K.L., P.J.-N., and F.R. are paid employees of Ionis Pharmaceuticals. The authors declare no other competing financial interests. This does not alter our adherence to PLOS ONE policies on sharing data and materials.