About the Authors

Sehyun Kim

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Current address: ABL Bio Inc., Seongnam, Republic of Korea

Affiliation Department of Neuroscience, Genentech Inc., South San Francisco, California, United States of America

Amy Stockwell

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization

Affiliation Department of Human Genetics, Genentech Inc., South San Francisco, California, United States of America

Han Qin

Roles Investigation, Methodology

Affiliation Department of Neuroscience, Genentech Inc., South San Francisco, California, United States of America

Simon S. Gao

Roles Investigation, Resources

Affiliation Department of Clinical Imaging, Genentech Inc., South San Francisco, California, United States of America

Meredith Sagolla

Roles Methodology, Resources

Affiliation Department of Research Pathology, Genentech Inc., South San Francisco, California, United States of America

Ivaylo Stoilov

Roles Conceptualization, Resources, Writing – review & editing

Affiliation Medical Affairs Ophthalmology, Genentech Inc., South San Francisco, California, United States of America

Arthur Wuster

Roles Formal analysis, Investigation, Methodology, Visualization

Current address: Department of Translational Genomics, BioMarin Pharmaceutical, San Rafael, California, United States of America

Affiliation Department of Human Genetics, Genentech Inc., South San Francisco, California, United States of America

Phillip Lai

Roles Investigation, Methodology

Affiliation Early Clinical Development, Genentech Inc., South San Francisco, California, United States of America

Brian L. Yaspan

Contributed equally to this work with: Brian L. Yaspan, Marion Jeanne

Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft

‡ BLY and MJ are joint senior authors to this work.

Affiliation Department of Human Genetics, Genentech Inc., South San Francisco, California, United States of America

Marion Jeanne

Contributed equally to this work with: Brian L. Yaspan, Marion Jeanne

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft

jeanne.marion@gene.com

‡ BLY and MJ are joint senior authors to this work.

Affiliation Department of Neuroscience, Genentech Inc., South San Francisco, California, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: at the time of the study, all authors were full time employees of Genentech/Roche with stock and stock options in Roche. This does not alter our adherence to PLOS ONE policies on sharing data and materials.