CCT6A knockdown suppresses osteosarcoma cell growth and Akt pathway activation in vitro

Weiquan Zeng; Meizhu Wu; Ying Cheng; Liya Liu; Yuying Han; Qiurong Xie; Jiapeng Li; Lihui Wei; Yi Fang; Youqin Chen; Jun Peng; Aling Shen

doi:10.1371/journal.pone.0279851

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Open Access

Peer-reviewed

Research Article

CCT6A knockdown suppresses osteosarcoma cell growth and Akt pathway activation in vitro

Weiquan Zeng ,

Contributed equally to this work with: Weiquan Zeng, Meizhu Wu, Ying Cheng

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliations Department of Orthopaedics, Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China
⨯
Meizhu Wu ,

Contributed equally to this work with: Weiquan Zeng, Meizhu Wu, Ying Cheng

Roles Investigation, Methodology, Writing – original draft

Affiliations Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China
⨯
Ying Cheng ,

Contributed equally to this work with: Weiquan Zeng, Meizhu Wu, Ying Cheng

Roles Methodology, Software, Writing – original draft

Affiliations Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China
⨯
Liya Liu,

Roles Investigation, Methodology, Software

Affiliations Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China
⨯
Yuying Han,

Roles Methodology, Resources

Affiliations Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China
⨯
Qiurong Xie,

Roles Investigation, Methodology

Affiliations Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China
⨯
Jiapeng Li,

Roles Software, Validation, Visualization

Affiliation Department of Physical Education, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China
⨯
Lihui Wei,

Roles Data curation, Formal analysis, Methodology

Affiliations Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China
⨯
Yi Fang,

Roles Data curation, Formal analysis, Methodology

Affiliations Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China
⨯
Youqin Chen,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Children’s Hospital, Cleveland, Ohio, United States of America
⨯
Jun Peng ,

Roles Data curation, Supervision, Writing – review & editing

* E-mail: pjunlab@hotmail.com (JP); saling86@hotmail.com (AS)

Affiliations Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China
⨯
Aling Shen

Roles Data curation, Funding acquisition, Writing – review & editing

* E-mail: pjunlab@hotmail.com (JP); saling86@hotmail.com (AS)

Affiliations Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China

https://orcid.org/0000-0002-5081-3523

⨯

CCT6A knockdown suppresses osteosarcoma cell growth and Akt pathway activation in vitro

Weiquan Zeng,
Meizhu Wu,
Ying Cheng,
Liya Liu,
Yuying Han,
Qiurong Xie,
Jiapeng Li,
Lihui Wei,
Yi Fang,
Youqin Chen

Published: December 30, 2022
https://doi.org/10.1371/journal.pone.0279851

About the Authors

Weiquan Zeng

Contributed equally to this work with: Weiquan Zeng, Meizhu Wu, Ying Cheng

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliations Department of Orthopaedics, Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China

Meizhu Wu

Contributed equally to this work with: Weiquan Zeng, Meizhu Wu, Ying Cheng

Roles Investigation, Methodology, Writing – original draft

Affiliations Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China

Ying Cheng

Contributed equally to this work with: Weiquan Zeng, Meizhu Wu, Ying Cheng

Roles Methodology, Software, Writing – original draft

Liya Liu

Roles Investigation, Methodology, Software

Yuying Han

Roles Methodology, Resources

Qiurong Xie

Roles Investigation, Methodology

Jiapeng Li

Roles Software, Validation, Visualization

Affiliation Department of Physical Education, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China

Lihui Wei

Roles Data curation, Formal analysis, Methodology

Yi Fang

Roles Data curation, Formal analysis, Methodology

Youqin Chen

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Children’s Hospital, Cleveland, Ohio, United States of America

Jun Peng

Roles Data curation, Supervision, Writing – review & editing

* E-mail: pjunlab@hotmail.com (JP); saling86@hotmail.com (AS)

Aling Shen

Roles Data curation, Funding acquisition, Writing – review & editing

* E-mail: pjunlab@hotmail.com (JP); saling86@hotmail.com (AS)

https://orcid.org/0000-0002-5081-3523

Competing Interests

The authors have declared that no competing interests exist.

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Transfection
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Small interfering RNA
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Apoptosis
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Cell cycle and cell division
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Cell growth
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Protein expression
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Cell staining
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Osteosarcoma cells
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