About the Authors

Margaret Sunitha Selvaraj

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, United States of America, Department of Medicine, Harvard Medical School, Boston, MA, United States of America

Kaavya Paruchuri

Roles Data curation

Affiliations Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, United States of America

Sara Haidermota

Roles Data curation

Affiliations Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, United States of America

Rachel Bernardo

Roles Data curation

Affiliations Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, United States of America

Stephen S. Rich

Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, VA, United States of America

Gina M. Peloso

Roles Conceptualization, Project administration, Supervision, Writing – original draft, Writing – review & editing

pnatarajan@mgh.harvard.edu (PN); gpeloso@bu.edu (GMP)

‡ GMP and PN are jointly supervised the work.

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America

Pradeep Natarajan

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

pnatarajan@mgh.harvard.edu (PN); gpeloso@bu.edu (GMP)

‡ GMP and PN are jointly supervised the work.

Affiliations Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, United States of America, Department of Medicine, Harvard Medical School, Boston, MA, United States of America

Competing Interests

P.N. reports grants from Amgen, Apple, AstraZeneca, Boston Scientific, and Novartis, personal fees from Apple, AstraZeneca, Blackstone Life Sciences, Foresite Labs, Genentech / Roche, Novartis, and TenSixteen Bio, equity in geneXwell, and TenSixteen Bio, co-founder of TenSixteen Bio, and spousal employment at Vertex, all unrelated to the present work. This does not alter our adherence to PLOS ONE policies on sharing data and materials.