About the Authors

Mark F. Bird

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Cardiovascular Sciences, Anaesthesia, Critical Care and Pain Management, University of Leicester, Leicester, United Kingdom

Barbara Gallacher-Horley

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Cardiovascular Sciences, Anaesthesia, Critical Care and Pain Management, University of Leicester, Leicester, United Kingdom

John McDonald

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Cardiovascular Sciences, Anaesthesia, Critical Care and Pain Management, University of Leicester, Leicester, United Kingdom

David G. McVey

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Cardiovascular Sciences, Anaesthesia, Critical Care and Pain Management, University of Leicester, Leicester, United Kingdom

Fatin Al-Janabi

Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Cardiovascular Sciences, Anaesthesia, Critical Care and Pain Management, University of Leicester, Leicester, United Kingdom

Remo Guerrini

Roles Conceptualization, Formal analysis, Resources, Writing – original draft, Writing – review & editing

Affiliation Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy

Girolamo Calo

Roles Conceptualization, Formal analysis, Resources, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy

Shu Ye

Roles Conceptualization, Formal analysis, Resources, Writing – original draft, Writing – review & editing

Affiliation Department of Cardiovascular Sciences, Anaesthesia, Critical Care and Pain Management, University of Leicester, Leicester, United Kingdom

Jonathan P. Thompson

Roles Conceptualization, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

Affiliation Department of Cardiovascular Sciences, Anaesthesia, Critical Care and Pain Management, University of Leicester, Leicester, United Kingdom

David G. Lambert

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

dgl3@le.ac.uk

Affiliation Department of Cardiovascular Sciences, Anaesthesia, Critical Care and Pain Management, University of Leicester, Leicester, United Kingdom

Competing Interests

Declaration of interests: DGL is a scientific adviser to Cellomatics, a SME-CRO. This does not alter our adherence to PLOS ONE policies on sharing data and materials.