About the Authors

Robert H. Shoemaker

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

Robert.Shoemaker@nih.gov

Affiliation Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Reynold A. Panettieri Jr.

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Rutgers Institute for Translational Medicine and Science, New Brunswick, New Jersey, United States of America

Steven K. Libutti

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Rutgers Cancer Institute, New Brunswick, New Jersey, United States of America

Howard S. Hochster

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Rutgers Cancer Institute, New Brunswick, New Jersey, United States of America

Norman R. Watts

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Protein Expression Laboratory, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Paul T. Wingfield

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Protein Expression Laboratory, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Philipp Starkl

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Medicine I, Laboratory of Infection Biology, Medical University of Vienna, Vienna, Austria

Lisabeth Pimenov

Roles Conceptualization, Data curation, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Medicine I, Laboratory of Infection Biology, Medical University of Vienna, Vienna, Austria

Riem Gawish

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Medicine I, Laboratory of Infection Biology, Medical University of Vienna, Vienna, Austria

Anastasiya Hladik

Roles Conceptualization, Data curation, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Medicine I, Laboratory of Infection Biology, Medical University of Vienna, Vienna, Austria

Sylvia Knapp

Roles Conceptualization, Data curation, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Medicine I, Laboratory of Infection Biology, Medical University of Vienna, Vienna, Austria

Daniel Boring

Roles Conceptualization, Data curation, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

Affiliation Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Jonathan M. White

Roles Conceptualization, Data curation, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

Affiliation MRIGlobal, Kansas City, Missouri, United States of America

Quentin Lawrence

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation MRIGlobal, Kansas City, Missouri, United States of America

Jeremy Boone

Roles Data curation, Formal analysis, Investigation

Affiliation MRIGlobal, Kansas City, Missouri, United States of America

Jason D. Marshall

Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Writing – original draft, Writing – review & editing

Affiliation Cancer ImmunoPrevention Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

Rebecca L. Matthews

Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Cancer ImmunoPrevention Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

Brian D. Cholewa

Roles Conceptualization, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

Affiliation Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Jeffrey W. Richig

Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation IIT Research Institute, Chicago, Illinois, United States of America

Ben T. Chen

Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation IIT Research Institute, Chicago, Illinois, United States of America

David L. McCormick

Roles Conceptualization, Data curation, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

Affiliation IIT Research Institute, Chicago, Illinois, United States of America

Romana Gugensberger

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Apeiron Biologics AG, Campus-Vienna-Biocenter 5, Vienna, Austria

Sonja Höller

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Apeiron Biologics AG, Campus-Vienna-Biocenter 5, Vienna, Austria

Josef M. Penninger

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Affiliations Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria, Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada

Gerald Wirnsberger

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Apeiron Biologics AG, Campus-Vienna-Biocenter 5, Vienna, Austria

Competing Interests

Gerald Wirnsberger and Sonja Holler and Romana Gugensberger were employed by Apeiron Biologics A.G. Apeiron supplied the APN01 for study. Josef M. Pettinger was a founder of Apeiron, is a current shareholder and inventor of APN01. David L. McCormick is a Section Editor for PLOS One. Other authors declare no competing interests.