About the Authors

Kumiko Shirai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – original draft

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Hayato Hikita

Roles Conceptualization, Data curation, Project administration, Writing – original draft, Writing – review & editing

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Sadatsugu Sakane

Roles Conceptualization, Data curation, Formal analysis

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Ryohei Narumi

Roles Investigation, Writing – original draft

Affiliation Laboratory of Proteome Research/Proteome for Drug Discovery, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan

Jun Adachi

Roles Investigation

Affiliation Laboratory of Proteome Research/Proteome for Drug Discovery, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan

Akira Doi

Roles Data curation, Resources

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Satoshi Tanaka

Roles Data curation, Resources

Affiliation Department of Gastroenterology and Hepatology, National Hospital Organization Osaka National Hospital, Chuoku, Osaka, Japan

Yuki Tahata

Roles Data curation, Resources

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Ryoko Yamada

Roles Data curation, Resources

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Takahiro Kodama

Roles Data curation, Resources

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Ryotaro Sakamori

Roles Data curation, Resources

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Tomohide Tatsumi

Roles Conceptualization, Data curation, Resources

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Eiji Mita

Roles Data curation, Resources

Affiliation Department of Gastroenterology and Hepatology, National Hospital Organization Osaka National Hospital, Chuoku, Osaka, Japan

Takeshi Tomonaga

Roles Investigation

Affiliation Laboratory of Proteome Research/Proteome for Drug Discovery, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan

Tetsuo Takehara

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

takehara@gh.med.osaka-u.ac.jp

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Competing Interests

Hayato Hikita is on the speakers’ bureau for Gilead Sciences, Inc, and AbbVie GK. Ryotaro Sakamori is on the speakers’ bureau for Gilead Sciences, Inc., MSD, and AbbVie GK. Tetsuo Takehara received grants from Gilead Sciences, Inc., MSD, and AbbVie GK and is on the speakers’ bureau for Gilead Sciences, Inc., MSD, and AbbVie GK. All of them don’t have competing interests relating to employment, consultancy, patents, products in development, and marketed products. Furthermore, the present work is not supported by funding from these commercial sources. This does not alter our adherence to PLOS ONE policies on sharing data and materials. All other authors declare that they have no conflicts of interest to disclose.