About the Authors

Dominique F. Leitner

Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Comprehensive Epilepsy Center, New York University School of Medicine, New York, New York, United States of America

Evgeny Kanshin

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Proteomics Laboratory, Division of Advanced Research Technologies, NYU School of Medicine, New York, New York, United States of America

Manor Askenazi

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliations Biomedical Hosting LLC, Arlington, Massachusetts, United States of America, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, United States of America

Yik Siu

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Metabolomics Core Resource Laboratory, New York University School of Medicine, New York, New York, United States of America

Daniel Friedman

Roles Investigation, Writing – review & editing

Affiliation Comprehensive Epilepsy Center, New York University School of Medicine, New York, New York, United States of America

Sasha Devore

Roles Project administration, Writing – review & editing

Affiliation Comprehensive Epilepsy Center, New York University School of Medicine, New York, New York, United States of America

Drew Jones

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Metabolomics Core Resource Laboratory, New York University School of Medicine, New York, New York, United States of America

Beatrix Ueberheide

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliations Proteomics Laboratory, Division of Advanced Research Technologies, NYU School of Medicine, New York, New York, United States of America, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, United States of America, Center for Cognitive Neurology, Department of Neurology, New York University School of Medicine, New York, New York, United States of America

Thomas Wisniewski

Roles Resources, Writing – review & editing

Affiliations Center for Cognitive Neurology, Department of Neurology, New York University School of Medicine, New York, New York, United States of America, Department of Psychiatry, New York University School of Medicine, New York, New York, United States of America, Department of Pathology, New York University School of Medicine, New York, New York, United States of America

Orrin Devinsky

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

Orrin.Devinsky@nyulangone.org

Affiliation Comprehensive Epilepsy Center, New York University School of Medicine, New York, New York, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: All the authors report no conflicts of interest. Below are the disclosures of the three authors: Daniel Friedman receives salary support for consulting and clinical trial related activities performed on behalf of The Epilepsy Study Consortium, a non-profit organization. Dr. Friedman receives no personal income for these activities. NYU receives a fixed amount from the Epilepsy Study Consortium towards Dr. Friedman’s salary. Within the past two years, The Epilepsy Study Consortium received payments for research services performed by Dr. Friedman from: Alterity, Baergic, Biogen, BioXcell, Cerevel, Cerebral, Jannsen, Lundbeck, Neurocrine, SK Life Science, and Xenon. He has also served as a paid consultant for Neurelis Pharmaceuticals and Receptor Life Sciences. He has received research support from NINDS, CDC, Epitel, and Neuropace unrelated to this study. He holds equity interests in Neuroview Technology. He received royalty income from Oxford University Press. Sasha Devore receives salary support from the National Institutes of Health, Department of Defense, and the Templeton World Charity Foundation unrelated to this study. Orrin Devinsky receives grant support from NINDS, NIMH, MURI, CDC and NSF. He has equity and/or compensation from the following companies: Tilray, Receptor Life Sciences, Qstate Biosciences, Tevard, Empatica, Engage, Egg Rock/Papa & Barkley, Rettco, SilverSpike, and California Cannabis Enterprises (CCE). He has received consulting fees from Zogenix, Ultragenyx, BridgeBio, and Marinus. He holds patents for the use of cannabidiol in treating neurological disorders but these are owned by GW Pharmaceuticals and he has waived any financial interests. He holds other patents in molecular biology. This does not alter our adherence to PLOS ONE policies on sharing data and materials.