About the Authors

Kouji Narita

Roles Conceptualization, Formal analysis, Investigation, Validation, Writing – original draft

Affiliations Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan, Institute for Animal Experimentation, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan

Krisana Asano

Roles Conceptualization, Writing – original draft

Affiliations Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan, Department of Biopolymer and Health Science, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan

Kyosuke Yamane

Roles Investigation, Writing – original draft

Affiliation Ushio Inc., Chiyoda-ku, Tokyo, Japan

Hiroyuki Ohashi

Roles Conceptualization, Writing – original draft

Affiliation Ushio Inc., Chiyoda-ku, Tokyo, Japan

Tatsushi Igarashi

Roles Conceptualization, Writing – original draft

Affiliation Ushio Inc., Chiyoda-ku, Tokyo, Japan

Akio Nakane

Roles Conceptualization, Project administration, Supervision, Writing – original draft

a27k03n0@hirosaki-u.ac.jp

Affiliations Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan, Department of Biopolymer and Health Science, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan

Competing Interests

I have read the journal’s policy and the authors of this manuscript Kyosuke Yamane, Hiroyuki Ohashi and Tatsushi Igarashi have the following competing interests: Kyosuke Yamane, Hiroyuki Ohashi and Tatsushi Igarashi are provided support in the form of salaries from Ushio Inc., Tokyo, Japan. This does not alter our adherence to PLOS ONE policies on sharing data and materials.