About the Authors

Rose D. L. Huang

Roles Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America

Xuan-Mai T. Nguyen

Roles Data curation, Writing – review & editing

Affiliations MAVERIC, VA Boston Healthcare System, Boston, Massachusetts, United States of America, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America

Gina M. Peloso

Roles Conceptualization, Writing – review & editing

Affiliations Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Mark Trinder

Roles Formal analysis, Writing – review & editing

Affiliations Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada, Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Daniel C. Posner

Roles Conceptualization, Formal analysis, Writing – review & editing

Affiliation MAVERIC, VA Boston Healthcare System, Boston, Massachusetts, United States of America

Krishna G. Aragam

Roles Conceptualization, Writing – review & editing

Affiliations Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Yuk-Lam Ho

Roles Data curation, Writing – review & editing

Affiliation MAVERIC, VA Boston Healthcare System, Boston, Massachusetts, United States of America

Julie A. Lynch

Roles Data curation, Writing – review & editing

Affiliations VA Informatics & Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, Utah, United States of America, College of Nursing & Health Sciences, University of Massachusetts Boston, Boston, Massachusetts, United States of America

Scott M. Damrauer

Roles Funding acquisition, Writing – review & editing

Affiliations Corporal Michael Crescenz VA Medical Center, Philadelphia, Pennsylvania, United States of America, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Kyong-Mi Chang

Roles Conceptualization, Writing – review & editing

Affiliations Corporal Michael Crescenz VA Medical Center, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Philip S. Tsao

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliations VA Palo Alto Health Care System, Palo Alto, California, United States of America, Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America

Pradeep Natarajan

Roles Conceptualization, Writing – review & editing

Affiliations Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Themistocles Assimes

Roles Conceptualization, Writing – review & editing

Affiliations VA Palo Alto Health Care System, Palo Alto, California, United States of America, Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America

J. Michael Gaziano

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliations MAVERIC, VA Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Aging, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

Luc Djousse

Roles Conceptualization, Data curation, Writing – review & editing

Affiliations MAVERIC, VA Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Aging, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

Kelly Cho

Roles Data curation, Funding acquisition, Writing – review & editing

Affiliations MAVERIC, VA Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Aging, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

Peter W. F. Wilson

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliations Atlanta VA Medical Center, Decatur, Georgia, United States of America, Emory University School of Medicine, Atlanta, Georgia, United States of America

Jennifer E. Huffman

Contributed equally to this work with: Jennifer E. Huffman, Christopher J. O’Donnell

Roles Conceptualization, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

Affiliation Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America

Christopher J. O’Donnell

Contributed equally to this work with: Jennifer E. Huffman, Christopher J. O’Donnell

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

christopher.odonnell@va.gov

Affiliations Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Heart & Vascular Center, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

on behalf of the Veterans Affairs’ Million Veteran Program

Million Veteran Program membership is provided in S2 File.

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: CJO: Employed by Novartis Institutes for Biomedical Research. SMD: Research support to my institution from RenalytixAI and paid consulting from Calico Labs, both outside the current work. PN: Research support from Amgen, Apple, and Boston Scientific, and personal consulting fees from Apple and Blackstone Life Sciences, all unrelated to the present work. This does not alter our adherence to PLOS ONE policies on sharing data and materials.