About the Authors

Andi Flory

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations PetDx, La Jolla, California, United States of America, Veterinary Specialty Hospital of San Diego, San Diego, California, United States of America, Veterinary Specialty Hospital of North County, San Marcos, California, United States of America

Kristina M. Kruglyak

Roles Data curation, Formal analysis, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliation PetDx, La Jolla, California, United States of America

John A. Tynan

Roles Conceptualization, Data curation, Investigation, Supervision, Validation

Affiliation PetDx, La Jolla, California, United States of America

Lisa M. McLennan

Roles Conceptualization, Data curation, Methodology, Project administration, Resources, Supervision

Affiliation PetDx, La Jolla, California, United States of America

Jill M. Rafalko

Roles Formal analysis, Project administration, Visualization, Writing – original draft, Writing – review & editing

jrafalko@petdx.com

Affiliation PetDx, La Jolla, California, United States of America

Patrick Christian Fiaux

Roles Data curation, Formal analysis, Software, Validation

Affiliation PetDx, La Jolla, California, United States of America

Gilberto E. Hernandez

Roles Data curation, Investigation, Methodology, Supervision, Validation

Affiliation PetDx, La Jolla, California, United States of America

Francesco Marass

Roles Data curation, Formal analysis, Methodology

Affiliation PetDx, La Jolla, California, United States of America

Prachi Nakashe

Roles Investigation, Methodology, Project administration, Validation

Affiliation PetDx, La Jolla, California, United States of America

Carlos A. Ruiz-Perez

Roles Data curation, Formal analysis, Methodology, Software

Affiliation PetDx, La Jolla, California, United States of America

Donna M. Fath

Roles Investigation, Project administration, Resources

Affiliation PetDx, La Jolla, California, United States of America

Thuy Jennings

Roles Supervision

Affiliation PetDx, La Jolla, California, United States of America

Rita Motalli-Pepio

Roles Data curation, Project administration

Affiliation PetDx, La Jolla, California, United States of America

Kate Wotrang

Roles Data curation, Investigation

Affiliation PetDx, La Jolla, California, United States of America

Angela L. McCleary-Wheeler

Roles Resources, Writing – review & editing

Affiliations PetDx, La Jolla, California, United States of America, Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri, United States of America

Susan Lana

Roles Investigation, Resources

Affiliation Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado, United States of America

Brenda Phillips

Roles Investigation, Resources, Writing – review & editing

Affiliation Veterinary Specialty Hospital of San Diego, San Diego, California, United States of America

Brian K. Flesner

Roles Investigation, Resources

Affiliations Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri, United States of America, Department of Clinical Science and Advanced Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Nicole F. Leibman

Roles Investigation, Resources

Affiliation The Animal Medical Center, New York, New York, United States of America

Tracy LaDue

Roles Investigation, Resources

Affiliation Southeast Veterinary Oncology and Internal Medicine, Orange Park, Florida, United States of America

Chelsea D. Tripp

Roles Data curation, Investigation, Resources

Affiliation Bridge Animal Referral Center, Edmonds, Washington, United States of America

Brenda L. Coomber

Roles Investigation, Resources

Affiliation Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

J. Paul Woods

Roles Investigation, Resources

Affiliation Institute for Comparative Cancer Investigation at the Mona Campbell Centre for Animal Cancer, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

Mairin Miller

Roles Investigation, Resources

Affiliation Veterinary Specialty Hospital of North County, San Marcos, California, United States of America

Sean W. Aiken

Roles Investigation, Resources

Affiliation Veterinary Specialty Hospital of San Diego, San Diego, California, United States of America

Amber Wolf-Ringwall

Roles Investigation, Resources

Affiliation Department of Veterinary Clinical Sciences, University of Minnesota, College of Veterinary Medicine, Saint Paul, Minnesota, United States of America

Antonella Borgatti

Roles Investigation, Resources

Affiliation Department of Veterinary Clinical Sciences, University of Minnesota, College of Veterinary Medicine, Saint Paul, Minnesota, United States of America

Kathleen Kraska

Roles Investigation, Resources, Writing – review & editing

Affiliation Veterinary Specialty Hospital of San Diego, San Diego, California, United States of America

Christopher B. Thomson

Roles Investigation, Resources, Writing – review & editing

Affiliation Veterinary Specialty Hospital of North County, San Marcos, California, United States of America

Alane Kosanovich Cahalane

Roles Investigation, Resources, Writing – review & editing

Affiliation Veterinary Specialty Hospital of Hong Kong, Wan Chai, Hong Kong

Rebecca L. Murray

Roles Investigation, Resources

Affiliation Bridge Animal Referral Center, Edmonds, Washington, United States of America

William C. Kisseberth

Roles Investigation, Resources

Affiliation Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, United States of America

Maria A. Camps-Palau

Roles Investigation, Resources

Affiliation The Animal Medical Center, New York, New York, United States of America

Franck Floch

Roles Investigation, Resources

Affiliations Oncovet, Villeneuve-D’ascq, France, AniCura TRIOVet, Rennes, France

Claire Beaudu-Lange

Roles Investigation, Resources

Affiliation Clinique Vétérinaire de la Pierre Bleue, Pipriac, France

Aurélia Klajer-Peres

Roles Investigation, Resources

Affiliation Eiffelvet, Paris, France

Olivier Keravel

Roles Investigation, Resources

Affiliation Eiffelvet, Paris, France

Luc-André Fribourg-Blanc

Roles Investigation, Resources

Affiliation Clinique Vétérinaire SeineVet, Rouen, France

Pascale Chicha Mazetier

Roles Investigation, Resources

Affiliation Clinique Vétérinaire Mazetier, Argenteuil, France

Angelo Marco

Roles Investigation, Resources

Affiliation Governor Animal Clinic, Inc., San Diego, California, United States of America

Molly B. McLeod

Roles Investigation, Resources

Affiliation City Paws Home Health, Columbus, Ohio, United States of America

Erin Portillo

Roles Investigation, Resources

Affiliation VCA Valley Oak Veterinary Center, Chico, California, United States of America

Terry S. Clark

Roles Investigation, Resources

Affiliation VCA Metroplex Animal Hospital, Irving, Texas, United States of America

Scott Judd

Roles Investigation, Resources

Affiliation Prices Creek Veterinary Services, Lewisburg, Ohio, United States of America

C. Kirk Feinberg

Roles Investigation, Resources

Affiliation Governor Animal Clinic, Inc., San Diego, California, United States of America

Marie Benitez

Roles Investigation, Resources

Affiliation Governor Animal Clinic, Inc., San Diego, California, United States of America

Candace Runyan

Roles Data curation, Investigation, Resources

Affiliation Carlsbad Animal Hospital, Carlsbad, California, United States of America

Lindsey Hackett

Roles Investigation, Resources

Affiliation Oceanside Veterinary Hospital, Oceanside, California, United States of America

Scott Lafey

Roles Investigation, Resources

Affiliation Amici Pet Hospital of Little Italy, San Diego, California, United States of America

Danielle Richardson

Roles Investigation, Resources

Affiliation Institute for Comparative Cancer Investigation at the Mona Campbell Centre for Animal Cancer, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

Sarah Vineyard

Roles Investigation, Resources

Affiliation Colony Veterinary Hospital, San Diego, California, United States of America

Mary Tefend Campbell

Roles Investigation, Resources

Affiliation Carriage Hills Animal Hospital, Montgomery, Alabama, United States of America

Nilesh Dharajiya

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing

Affiliations Healthbit.ai Inc., San Diego, California, United States of America, Advisor to PetDx, La Jolla, California, United States of America

Taylor J. Jensen

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing

Affiliations Laboratory Corporation of America, Durham, North Carolina, United States of America, Advisor to PetDx, La Jolla, California, United States of America

Dirk van den Boom

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing

Affiliation Advisor to PetDx, La Jolla, California, United States of America

Luis A. Diaz Jr.

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing

Affiliations Advisor to PetDx, La Jolla, California, United States of America, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America

Daniel S. Grosu

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation PetDx, La Jolla, California, United States of America

Arthur Polk

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation PetDx, La Jolla, California, United States of America

Kalle Marsal

Roles Funding acquisition, Writing – review & editing

Affiliation PetDx, La Jolla, California, United States of America

Susan Cho Hicks

Roles Supervision, Writing – review & editing

Affiliation PetDx, La Jolla, California, United States of America

Katherine M. Lytle

Roles Writing – review & editing

Affiliation PetDx, La Jolla, California, United States of America

Lauren Holtvoigt

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision

Affiliation PetDx, La Jolla, California, United States of America

Jason Chibuk

Roles Project administration, Writing – original draft, Writing – review & editing

Affiliation PetDx, La Jolla, California, United States of America

Ilya Chorny

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Software, Supervision, Writing – review & editing

Affiliation PetDx, La Jolla, California, United States of America

Dana W. Y. Tsui

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation PetDx, La Jolla, California, United States of America

Competing Interests

AF, KMK, JAT, LMM, JMR, PCF, GEH, FM, PN, CAR-P, DMF, TJ, RM-P, KW, ALM-W, DSG, AP, KM, SCH, KML, LH, JC, IC, and DWYT are employed by or affiliated with PetDx; and receive compensation from PetDx and/or hold vested or unvested equity in PetDx. Drs. Flesner and Leibman are members of the PetDx clinical advisory board and receive compensation and equity. Dr. Borgatti has ownership interest (including patents) in a patent entitled “Reduction of EGFR therapeutic toxicity” filed by the University of Minnesota Office of Technology Commercialization. Drs. Cahalane, Phillips, and Aiken are investors in PetDx. Drs. Jensen, van den Boom, Dharajiya, and Diaz are advisors for PetDx and hold vested or unvested equity in PetDx. Drs. Chorny, Kruglyak, Grosu, Marass, Ruiz-Perez and Tsui hold pending patent applications related to technology described in this work. This does not alter our adherence to PLOS ONE policies on sharing data and materials.