Chloroquine and COVID-19—A systems biology model uncovers the drug’s detrimental effect on autophagy and explains its failure

Orsolya Kapuy; Tamás Korcsmáros

doi:10.1371/journal.pone.0266337

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Open Access

Peer-reviewed

Research Article

Chloroquine and COVID-19—A systems biology model uncovers the drug’s detrimental effect on autophagy and explains its failure

Orsolya Kapuy ,

Roles Conceptualization, Data curation, Methodology, Validation, Writing – original draft, Writing – review & editing

* E-mail: kapuy.orsolya@med.semmelweis-univ.hu

Affiliation Semmelweis University, Department of Molecular Biology at the Institute of Biochemistry and Molecular Biology, Budapest, Hungary
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Tamás Korcsmáros

Roles Conceptualization, Data curation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliations Earlham Institute, Norwich Research Park, Norwich, United Kingdom, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom

https://orcid.org/0000-0003-1717-996X

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Chloroquine and COVID-19—A systems biology model uncovers the drug’s detrimental effect on autophagy and explains its failure

Orsolya Kapuy,
Tamás Korcsmáros

Published: April 7, 2022
https://doi.org/10.1371/journal.pone.0266337

About the Authors

Orsolya Kapuy

Roles Conceptualization, Data curation, Methodology, Validation, Writing – original draft, Writing – review & editing

* E-mail: kapuy.orsolya@med.semmelweis-univ.hu

Affiliation Semmelweis University, Department of Molecular Biology at the Institute of Biochemistry and Molecular Biology, Budapest, Hungary

Tamás Korcsmáros

Roles Conceptualization, Data curation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliations Earlham Institute, Norwich Research Park, Norwich, United Kingdom, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom

https://orcid.org/0000-0003-1717-996X

Competing Interests

The authors have declared that no competing interests exist.

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Autophagic cell death
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Apoptosis
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SARS CoV 2
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COVID 19
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Host cells
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Chloroquine
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Endoplasmic reticulum
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Systems biology
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