About the Authors

Michikazu Nakai

Roles Formal analysis, Writing – original draft

nakai.michikazu@ncvc.go.jp

Affiliation National Cerebral and Cardiovascular Center, Suita, Japan

Yoshitaka Iwanaga

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation National Cerebral and Cardiovascular Center, Suita, Japan

Yoko Sumita

Roles Data curation, Methodology

Affiliation National Cerebral and Cardiovascular Center, Suita, Japan

Shinichi Wada

Roles Conceptualization, Data curation, Visualization

Affiliation National Cerebral and Cardiovascular Center, Suita, Japan

Haruhiko Hiramatsu

Roles Conceptualization, Data curation

Affiliation National Cerebral and Cardiovascular Center, Suita, Japan

Koji Iihara

Roles Conceptualization, Supervision

Affiliation National Cerebral and Cardiovascular Center, Suita, Japan

Takahide Kohro

Roles Conceptualization, Visualization

Affiliation Department of Medical Informatics, Jichi Medical University Hospital, Shimotsuke, Japan

Issei Komuro

Roles Conceptualization, Data curation, Supervision

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Tomohiro Kuroda

Roles Conceptualization, Data curation, Supervision

Affiliation Division of Medical Information Technology and Administration Planning, Kyoto University Hospital, Kyoto, Japan

Tetsuya Matoba

Roles Conceptualization, Data curation

Affiliation Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

Masaharu Nakayama

Roles Conceptualization, Data curation, Supervision

Affiliation Department of Medical Informatics, Tohoku University Graduate School of Medicine, Sendai, Japan

Kunihiro Nishimura

Roles Conceptualization, Data curation

Affiliation National Cerebral and Cardiovascular Center, Suita, Japan

Teruo Noguchi

Roles Conceptualization, Data curation, Supervision

Affiliation National Cerebral and Cardiovascular Center, Suita, Japan

Tadamasa Takemura

Roles Conceptualization, Data curation

Affiliation Graduate School of Applied Informatics, University of Hyogo, Kobe, Japan

Teiji Tominaga

Roles Conceptualization, Data curation, Supervision

Affiliation Department of Neurosurgery, Tohoku University Hospital, Tohoku University Graduate School of Medicine, Sendai, Japan

Kazunori Toyoda

Roles Conceptualization, Data curation, Supervision

Affiliation National Cerebral and Cardiovascular Center, Suita, Japan

Kenichi Tsujita

Roles Conceptualization, Data curation, Supervision

Affiliation Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

Satoshi Yasuda

Roles Conceptualization, Data curation, Supervision

Affiliation Department of Cardiovascular Medicine, Tohoku University Hospital, Tohoku University Graduate School of Medicine, Sendai, Japan

Yoshihiro Miyamoto

Roles Conceptualization, Data curation, Supervision

Affiliation National Cerebral and Cardiovascular Center, Suita, Japan

Hisao Ogawa

Roles Conceptualization, Data curation, Supervision, Writing – review & editing

Affiliation President, Kumamoto University, Kumamoto, Japan

Competing Interests

Dr. Iihara reports personal fees and other funding from Megwell, personal fees from Daiichi Sankyo. Co. Ltd., personal fees from Otsuka Pharmaceutical, and grants from Idorsia Pharmaceuticals Japan outside of the submitted work. Dr. Komuro reports grants and personal fees from Daiichi Sankyo Company, Ltd., grants from Sumitomo Dainippon Pharma Co., Ltd., grants and personal fees from Takeda Pharmaceutical Company Ltd., grants from Mitsubishi Tanabe Pharma Corporation, grants from Teijin Pharma Ltd., grants from Idorsia Pharmaceuticals Ltd., grants from Otsuka Pharmaceutical Co., Ltd., grants and personal fees from Bayer Yakuhin, Ltd., grants and personal fees from Ono Pharmaceutical Co., Ltd., grants from Toa Eiyo Ltd., and personal fees from AstraZeneca, and personal fees from Pfizer Japan Inc. outside of the submitted work. Dr. Matoba reports grants and personal fees from Bayer Yakuhin, Ltd., grants from Amgen, personal fees from Merck & Co., Inc., and personal fees from Abbott Vascular outside of the submitted work. Dr. Nishimura reports personal fees from Philips Japan, Ltd., personal fees from Tokyo Electric Power Company, personal fees from Terumo Company, and personal fees from H.U. group holdings outside of the submitted work. Dr. Nakayama reports personal fees from Pfizer Japan Inc, AstraZeneca K.K., Astellas Pharma Inc., Toppan Forms Co., InterSystems Corporation, Fujitsu Research Institute, Nikkei Business Publications, Inc., NIHON KOHDEN Co., FUKUDA DENSHI, Deloitte Tohmatsu Consulting LLC, and PwC Consulting LLC, outside of the submitted work. Dr. Toyoda reports personal fees from Daiichi-Sankyo, personal fees from Bayer Yakuhin, personal fees from Bristol-Myers-Squibb, personal fees from Outsuka Pharmaceutical Company Ltd., personal fees from Novartis Pharma Japan., and personal fees from Abbott Medical Japan Co., Ltd.,outside of the submitted work. Dr. Tsujita reports personal fees from Amgen K.K., grants and personal fees from Bayer Yakuhin, Ltd., grants and personal fees from Daiichi Sankyo Co., Ltd., personal fees from Kowa Pharmaceutical Co. Ltd., personal fees from Novartis Pharma K.K., grants and personal fees from Otsuka Pharmaceutical Co., Ltd., personal fees from Pfizer Japan Inc., grants from AMI Co., Ltd., grants from Bristol-Myers K.K., grants from EA Pharma Co. Ltd., grants from Mochida Pharmaceutical Co., Ltd., grants from Nippon Boehringer Ingelheim, grants from Chugai Pharmaceutical Co., Ltd., grants from Edwards Lifesciences Corporation., grants from Johnson & Johnson K.K., grants from Ono Pharmaceutical Co., Ltd., grants from Takeda Pharmaceutical Co., Ltd., other funding from Abbott Japan Co., Ltd., other funding from Boston Scientific Japan K.K., other funding from Fides-one, Inc., other funding from ITI Co., Ltd., other funding from Kaneka Medix Co., Ltd., other funding from Nipro Corporation, other funding from Terumo Co., Ltd., other funding from Abbott Medical Co., Ltd., other funding from Cardinal Health Japan, other funding from Fides-one, Inc., other funding from Fukuda Denshi Co., Ltd., other funding from Japan Lifeline Co., Ltd., other funding from Medical Appliance Co., Ltd., and other funding from Medtronic Japan Co., Ltd. outside of the submitted work. Dr. Yasuda reports personal fees from Bristol-Meyers, grants and personal fees from Bayer, personal fees from Daiichi-Sankyo, grants and other funding from Takeda Pharmaceutical Company Ltd., grants from NEC, grants from Daiichi-Sankyo, grants and other funding from Abbott, other funding from Terumo Co., Ltd., other funding from Nihon Kohden, other funding from Medtronic, other funding from Japan Lifeline, other funding from Otsuka, other funding from Ono, other funding from Nippon Boehringer Ingelheim, other funding from Kowa, other funding from Zeon, other funding from Shionogi, other funding from Nippon-Shinyaku, other funding from Mochida, and other funding from Tesco outside of the submitted work. Dr. Miyamoto reports personal fees from Tokyo Marine, personal fees from Nichido Fire Insurance Co., Ltd., personal fees from Fujitsu Co., Ltd., personal fees from Softbank Co., Ltd., personal fees from Meiji Yasuda Life Insurance Company., and personal fees from Saraya Co., Ltd. outside of the submitted work. Dr. Ogawa reports personal fees from Towa Pharmaceutical Co., Ltd., personal fees from Bristol-Meyers Squibb Co., Ltd., personal fees from Pfizer Co., Ltd., personal fees from Toa Eiyo Co., Ltd., personal fees from Bayer Yakuhin Co., Ltd., and personal fees from Novartis Pharma Co., Ltd., personal fees from Takeda Pharmaceutical Co., LTD, personal fees from Daiichisankyo Co., Ltd., personal fees from Eisai Co., Ltd., personal fees from Teijin Co., Ltd. personal fees from Behringer Ingelheim Co., Ltd., Abbott Medical Japan Co., Ltd. outside of the submitted work. No other potential conflict of interest relevant to this article was reported. There are no patents, products in development or marketed products associated with this research to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials.