About the Authors

Ryan Schubert

Roles Conceptualization, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Mathematics and Statistics, Loyola University Chicago, Chicago, IL, United States of America, Department of Biology, Loyola University Chicago, Chicago, IL, United States of America, Program in Bioinformatics, Loyola University Chicago, Chicago, IL, United States of America

Elyse Geoffroy

Roles Formal analysis, Writing – review & editing

Affiliation Program in Bioinformatics, Loyola University Chicago, Chicago, IL, United States of America

Isabelle Gregga

Roles Formal analysis, Writing – review & editing

Affiliation Department of Biology, Loyola University Chicago, Chicago, IL, United States of America

Ashley J. Mulford

Roles Formal analysis, Writing – review & editing

Affiliations Department of Biology, Loyola University Chicago, Chicago, IL, United States of America, Program in Bioinformatics, Loyola University Chicago, Chicago, IL, United States of America

Francois Aguet

Roles Resources

Affiliation Broad Institute, Cambridge, MA, United States of America

Kristin Ardlie

Roles Resources

Affiliation Broad Institute, Cambridge, MA, United States of America

Robert Gerszten

Roles Data curation, Resources

Affiliation Beth Israel Deaconess Medical Center, Boston, MA, United States of America

Clary Clish

Roles Resources

Affiliation Broad Institute, Cambridge, MA, United States of America

David Van Den Berg

Roles Resources

Affiliation University of Southern California, Los Angeles, CA, United States of America

Kent D. Taylor

Roles Resources

Affiliation The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States of America

Peter Durda

Roles Resources

Affiliation Laboratory for Clinical Biochemistry Research, University of Vermont, Burlington, VT, United States of America

W. Craig Johnson

Roles Data curation

Affiliation Collaborative Health Studies Coordinating Center, University of Washington, Seattle, WA, United States of America

Elaine Cornell

Roles Resources

Affiliation Laboratory for Clinical Biochemistry Research, University of Vermont, Burlington, VT, United States of America

Xiuqing Guo

Roles Data curation, Resources

Affiliation The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States of America

Yongmei Liu

Roles Resources

Affiliation Department of Medicine, Duke University School of Medicine, Durham, NC, United States of America

Russell Tracy

Roles Resources

Affiliation Laboratory for Clinical Biochemistry Research, University of Vermont, Burlington, VT, United States of America

Matthew Conomos

Roles Data curation

Affiliation Department of Biostatistics, University of Washington, Seattle, WA, United States of America

Tom Blackwell

Roles Resources, Writing – review & editing

Affiliation Department of Biostatistics, University of Michigan, Ann Arbor, MI, United States of America

George Papanicolaou

Roles Resources

Affiliation Epidemiology Branch, National Heart, Lung and Blood Institute, Bethesda, MD, United States of America

Tuuli Lappalainen

Roles Resources, Writing – review & editing

Affiliation New York Genome Center and Department of Systems Biology, Columbia University, New York, NY United States of America

Anna V. Mikhaylova

Roles Resources, Writing – review & editing

Affiliation Department of Biostatistics, University of Washington, Seattle, WA, United States of America

Timothy A. Thornton

Roles Resources, Writing – review & editing

Affiliation Department of Biostatistics, University of Washington, Seattle, WA, United States of America

Michael H. Cho

Roles Resources, Writing – review & editing

Affiliation Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, United States of America

Christopher R. Gignoux

Roles Resources, Writing – review & editing

Affiliation Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America

Leslie Lange

Roles Resources, Writing – review & editing

Affiliation Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America

Ethan Lange

Roles Resources, Writing – review & editing

Affiliation Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America

Stephen S. Rich

Roles Funding acquisition, Methodology, Resources, Writing – review & editing

Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, VA, United States of America

Jerome I. Rotter

Roles Funding acquisition, Project administration, Resources, Writing – review & editing

Affiliation The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States of America

NHLBI TOPMed Consortium

Membership list can be found in the S8 Table.

Ani Manichaikul

Roles Methodology, Resources, Writing – review & editing

Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, VA, United States of America

Hae Kyung Im

Roles Methodology, Resources, Writing – review & editing

Affiliation Section of Genetic Medicine, The University of Chicago, Chicago, IL, United States of America

Heather E. Wheeler

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Visualization, Writing – original draft, Writing – review & editing

hwheeler1@luc.edu

Affiliations Department of Biology, Loyola University Chicago, Chicago, IL, United States of America, Program in Bioinformatics, Loyola University Chicago, Chicago, IL, United States of America

Competing Interests

The authors have declared that no competing interests exist.