Hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial

Keren Doenyas-Barak; Merav Catalogna; Ilan Kutz; Gabriela Levi; Amir Hadanny; Sigal Tal; Shir Daphna-Tekoha; Efrat Sasson; Yarden Shechter; Shai Efrati

doi:10.1371/journal.pone.0264161

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Peer-reviewed

Research Article

Hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial

Keren Doenyas-Barak ,

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Conceptualization, Investigation, Methodology, Writing – original draft

* E-mail: Kerendoenyas@gmail.com

Affiliations The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center Zerifin, Zerifin, Israel, Sackler School of Medicine Tel-Aviv University, Tel-Aviv, Israel

https://orcid.org/0000-0002-9212-5075

⨯
Merav Catalogna ,

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Data curation, Formal analysis, Methodology, Software, Writing – review & editing

Affiliation The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center Zerifin, Zerifin, Israel
⨯
Ilan Kutz ,

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Supervision, Writing – review & editing

Affiliation The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center Zerifin, Zerifin, Israel
⨯
Gabriela Levi ,

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Data curation, Project administration, Writing – review & editing

Affiliation The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center Zerifin, Zerifin, Israel
⨯
Amir Hadanny ,

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Methodology, Supervision, Validation, Writing – review & editing

Affiliations The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center Zerifin, Zerifin, Israel, Sackler School of Medicine Tel-Aviv University, Tel-Aviv, Israel

https://orcid.org/0000-0001-9028-7268

⨯
Sigal Tal ,

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Formal analysis, Writing – review & editing

Affiliations Sackler School of Medicine Tel-Aviv University, Tel-Aviv, Israel, Radiology Department, Shamir Medical Center, Zerifin, Israel
⨯
Shir Daphna-Tekoha ,

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Investigation, Supervision, Writing – review & editing

Affiliations Kaplan Medical Center, Rehovot, Israel, Faculty of Social-Work, Ashkelon Academic College, Ashkelon, Israel, Emili Sagol Creative Arts Therapies Research Center, Mount Carmel, Haifa, Israel
⨯
Efrat Sasson ,

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Formal analysis, Software, Validation, Writing – review & editing

Affiliation The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center Zerifin, Zerifin, Israel
⨯
Yarden Shechter ,

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Investigation, Project administration

Affiliation The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center Zerifin, Zerifin, Israel
⨯
Shai Efrati

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Conceptualization, Resources, Supervision, Validation, Writing – review & editing

Affiliations The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center Zerifin, Zerifin, Israel, Sackler School of Medicine Tel-Aviv University, Tel-Aviv, Israel, Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel
⨯

Hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial

Keren Doenyas-Barak,
Merav Catalogna,
Ilan Kutz,
Gabriela Levi,
Amir Hadanny,
Sigal Tal,
Shir Daphna-Tekoha,
Efrat Sasson,
Yarden Shechter,
Shai Efrati

Published: February 22, 2022
https://doi.org/10.1371/journal.pone.0264161

About the Authors

Keren Doenyas-Barak

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Conceptualization, Investigation, Methodology, Writing – original draft

* E-mail: Kerendoenyas@gmail.com

Affiliations The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center Zerifin, Zerifin, Israel, Sackler School of Medicine Tel-Aviv University, Tel-Aviv, Israel

https://orcid.org/0000-0002-9212-5075

Merav Catalogna

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Data curation, Formal analysis, Methodology, Software, Writing – review & editing

Affiliation The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center Zerifin, Zerifin, Israel

Ilan Kutz

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Supervision, Writing – review & editing

Affiliation The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center Zerifin, Zerifin, Israel

Gabriela Levi

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Data curation, Project administration, Writing – review & editing

Affiliation The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center Zerifin, Zerifin, Israel

Amir Hadanny

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Methodology, Supervision, Validation, Writing – review & editing

Affiliations The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center Zerifin, Zerifin, Israel, Sackler School of Medicine Tel-Aviv University, Tel-Aviv, Israel

https://orcid.org/0000-0001-9028-7268

Sigal Tal

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Formal analysis, Writing – review & editing

Affiliations Sackler School of Medicine Tel-Aviv University, Tel-Aviv, Israel, Radiology Department, Shamir Medical Center, Zerifin, Israel

Shir Daphna-Tekoha

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Investigation, Supervision, Writing – review & editing

Affiliations Kaplan Medical Center, Rehovot, Israel, Faculty of Social-Work, Ashkelon Academic College, Ashkelon, Israel, Emili Sagol Creative Arts Therapies Research Center, Mount Carmel, Haifa, Israel

Efrat Sasson

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Formal analysis, Software, Validation, Writing – review & editing

Affiliation The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center Zerifin, Zerifin, Israel

Yarden Shechter

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Investigation, Project administration

Affiliation The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center Zerifin, Zerifin, Israel

Shai Efrati

Contributed equally to this work with: Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati

Roles Conceptualization, Resources, Supervision, Validation, Writing – review & editing

Affiliations The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center Zerifin, Zerifin, Israel, Sackler School of Medicine Tel-Aviv University, Tel-Aviv, Israel, Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel

Competing Interests

AH and ES works for AVIV scientific. SE is a shareholder in AVIV scientific.

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Post-traumatic stress disorder
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Hippocampus
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Memory
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Functional magnetic resonance imaging
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Microstructure
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Drug therapy
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Mental health therapies
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