Comparative analysis of hypertensive nephrosclerosis in animal models of hypertension and its relevance to human pathology. Glomerulopathy

Alex A. Gutsol; Paula Blanco; Taben M. Hale; Jean-Francois Thibodeau; Chet E. Holterman; Rania Nasrallah; Jose W. N. Correa; Sergey A. Afanasiev; Rhian M. Touyz; Chris R. J. Kennedy; Dylan Burger; Richard L. Hébert; Kevin D. Burns

doi:10.1371/journal.pone.0264136

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Open Access

Peer-reviewed

Research Article

Comparative analysis of hypertensive nephrosclerosis in animal models of hypertension and its relevance to human pathology. Glomerulopathy

Alex A. Gutsol ,

Contributed equally to this work with: Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns

Roles Conceptualization

* E-mail: agutsol@uottawa.ca

Affiliation Ottawa Hospital Research Institute & Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada

https://orcid.org/0000-0002-6251-1338

⨯
Paula Blanco ,

Contributed equally to this work with: Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns

Roles Methodology

Affiliation Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON, Canada
⨯
Taben M. Hale ,

Contributed equally to this work with: Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns

Roles Data curation, Investigation, Writing – review & editing

Affiliation Basic Medical Sciences Faculty, University of Arizona, Tucson, AZ, United States of America
⨯
Jean-Francois Thibodeau ,

Contributed equally to this work with: Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns

Roles Investigation

Affiliation Ottawa Hospital Research Institute & Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada
⨯
Chet E. Holterman ,

Contributed equally to this work with: Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns

Roles Data curation, Investigation, Writing – original draft, Writing – review & editing

Affiliation Ottawa Hospital Research Institute & Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada
⨯
Rania Nasrallah ,

Contributed equally to this work with: Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns

Roles Data curation, Investigation

Affiliation Ottawa Hospital Research Institute & Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada
⨯
Jose W. N. Correa ,

Contributed equally to this work with: Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Physiological Sciences, Biological Sciences Institute, Federal University of Amazonas, Manaus, Brazil

https://orcid.org/0000-0002-9580-3361

⨯
Sergey A. Afanasiev ,

Contributed equally to this work with: Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns

Roles Conceptualization, Investigation, Writing – review & editing

Affiliation Cardiology Research Institute, Tomsk, Russian Federation
⨯
Rhian M. Touyz ,

Contributed equally to this work with: Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns

Roles Conceptualization, Data curation

Affiliation Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada
⨯
Chris R. J. Kennedy ,

Contributed equally to this work with: Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns

Roles Data curation, Formal analysis, Supervision, Writing – original draft

Affiliations Ottawa Hospital Research Institute & Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada
⨯
Dylan Burger ,

Contributed equally to this work with: Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns

Roles Investigation, Validation, Visualization

Affiliations Ottawa Hospital Research Institute & Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada
⨯
Richard L. Hébert ,

Contributed equally to this work with: Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns

Roles Supervision

Affiliations Ottawa Hospital Research Institute & Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada
⨯
Kevin D. Burns

Contributed equally to this work with: Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns

Roles Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliations Ottawa Hospital Research Institute & Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada, Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
⨯

Comparative analysis of hypertensive nephrosclerosis in animal models of hypertension and its relevance to human pathology. Glomerulopathy

Alex A. Gutsol,
Paula Blanco,
Taben M. Hale,
Jean-Francois Thibodeau,
Chet E. Holterman,
Rania Nasrallah,
Jose W. N. Correa,
Sergey A. Afanasiev,
Rhian M. Touyz,
Chris R. J. Kennedy

Published: February 17, 2022
https://doi.org/10.1371/journal.pone.0264136

About the Authors

Alex A. Gutsol

Contributed equally to this work with: Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns

Roles Conceptualization

* E-mail: agutsol@uottawa.ca

Affiliation Ottawa Hospital Research Institute & Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada

https://orcid.org/0000-0002-6251-1338

Paula Blanco

Roles Methodology

Affiliation Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON, Canada

Taben M. Hale

Roles Data curation, Investigation, Writing – review & editing

Affiliation Basic Medical Sciences Faculty, University of Arizona, Tucson, AZ, United States of America

Jean-Francois Thibodeau

Roles Investigation

Affiliation Ottawa Hospital Research Institute & Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada

Chet E. Holterman

Roles Data curation, Investigation, Writing – original draft, Writing – review & editing

Affiliation Ottawa Hospital Research Institute & Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada

Rania Nasrallah

Roles Data curation, Investigation

Affiliation Ottawa Hospital Research Institute & Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada

Jose W. N. Correa

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Physiological Sciences, Biological Sciences Institute, Federal University of Amazonas, Manaus, Brazil

https://orcid.org/0000-0002-9580-3361

Sergey A. Afanasiev

Roles Conceptualization, Investigation, Writing – review & editing

Affiliation Cardiology Research Institute, Tomsk, Russian Federation

Rhian M. Touyz

Roles Conceptualization, Data curation

Affiliation Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada

Chris R. J. Kennedy

Roles Data curation, Formal analysis, Supervision, Writing – original draft

Affiliations Ottawa Hospital Research Institute & Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada

Dylan Burger

Roles Investigation, Validation, Visualization

Richard L. Hébert

Roles Supervision

Kevin D. Burns

Roles Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliations Ottawa Hospital Research Institute & Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada, Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada

Competing Interests

The authors have declared that no competing interests exist.

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Kidneys
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Glomeruli
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Hypertension
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Mouse models
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Animal studies
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