About the Authors

Paulo D’Amora

Contributed equally to this work with: Paulo D’Amora, Ismael Dale C. G. Silva, Maria Auxiliadora Budib

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

d.amora@unifesp.br

Affiliations Department of Gynecology, Molecular Gynecology and Metabolomics Lab, College of Medicine of the Federal University of São Paulo (EPM-UNIFESP), São Paulo, São Paulo, Brazil, Nagourney Institute, Long Beach, California, United States of America, Metabolomycs, Inc., Long Beach, California, United States of America

Ismael Dale C. G. Silva

Contributed equally to this work with: Paulo D’Amora, Ismael Dale C. G. Silva, Maria Auxiliadora Budib

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – review & editing

‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

Affiliations Department of Gynecology, Molecular Gynecology and Metabolomics Lab, College of Medicine of the Federal University of São Paulo (EPM-UNIFESP), São Paulo, São Paulo, Brazil, Nagourney Cancer Institute, Long Beach, California, United States of America

Maria Auxiliadora Budib

Contributed equally to this work with: Paulo D’Amora, Ismael Dale C. G. Silva, Maria Auxiliadora Budib

Roles Data curation, Investigation, Resources

Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

Ricardo Ayache

Roles Data curation, Investigation, Resources

‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

Rafaela Moraes Siufi Silva

Roles Data curation, Investigation, Resources

‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

Fabricio Colacino Silva

Roles Data curation, Investigation, Resources

‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

Robson Mateus Appel

Roles Data curation, Investigation, Resources

‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

Saturnino Sarat Júnior

Roles Data curation, Investigation, Resources

‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

Henrique Budib Dorsa Pontes

Roles Data curation, Investigation, Resources

‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

Ana Carolina Alvarenga

Roles Data curation, Investigation, Resources

‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

Emilli Carvalho Arima

Roles Data curation, Investigation, Resources

‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

Wellington Galhano Martins

Roles Data curation, Investigation, Resources

Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

Nakal Laurenço F. Silva

Roles Data curation, Investigation, Resources

Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

Ricardo Sobhie Diaz

Roles Data curation, Investigation, Resources, Supervision

‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

Affiliation Department of Medicine, Infectious Disease Division, Retrovirology Laboratory, College of Medicine of the Federal University of São Paulo (EPM-UNIFESP), São Paulo, São Paulo, Brazil

Marcia B. Salzgeber

Roles Data curation, Investigation, Resources

Affiliation Department of Gynecology, Molecular Gynecology and Metabolomics Lab, College of Medicine of the Federal University of São Paulo (EPM-UNIFESP), São Paulo, São Paulo, Brazil

Anton M. Palma

Roles Data curation, Formal analysis, Methodology, Validation

Affiliation Institute for Clinical and Translational Science (ICTS), University of California Irvine (UCI), Irvine, California, United States of America

Steven S. Evans

Roles Data curation, Investigation, Resources, Supervision

Affiliations Nagourney Institute, Long Beach, California, United States of America, Metabolomycs, Inc., Long Beach, California, United States of America, Nagourney Cancer Institute, Long Beach, California, United States of America

Robert A. Nagourney

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

Affiliations Nagourney Institute, Long Beach, California, United States of America, Metabolomycs, Inc., Long Beach, California, United States of America, Nagourney Cancer Institute, Long Beach, California, United States of America, Todd Cancer Institute, Memorial Medical Center of Long Beach, Long Beach, California, United States of America, Department of Obstetrics and Gynecology, University of California Irvine (UCI), Orange, California, United States of America

Competing Interests

R.S. Diaz, M.A. Budib, R. Ayache, R.M.S. Silva, F.C. Silva, S.S. Júnior, H.B.D. Pontes, A.C. Alvarenga, E.C. Arima, W.G. Martins, N.L.F. Silva, M.B. Salzgeber and A.M. Palma have no conflicts of interest to declare. P. D’Amora (consultation: Metabolomycs, Inc.; intellectual property rights (patent pending) Metabolomycs, Inc.; stockholder: Metabolomycs, Inc.). S.S. Evans (stockholder: Metabolomycs, Inc.). I.D.C.G. da Silva (consultation, Metabolomycs, Inc.; intellectual property (patent pending) Metabolomycs, Inc.; board director Metabolomycs, Inc.; stockholder: Metabolomycs, Inc.). R.A. Nagourney (intellectual property rights (patent pending) Metabolomycs, Inc.; board director: Nagourney Institute, board director Metabolomycs, Inc.; stockholder: Metabolomycs, Inc.). Robson Mateus Appel (RMA) was reimbursed for patient registration and sample collection costs by Metabolomycs, Inc. Dr. D’Amora and Dr da Silva of UNIFESP, receive consulting fees from Metabolomycs, Inc. for their cancer-related metabolomic research. We certify that the submission is original work and is not under review at any other publication.