About the Authors

Yasuhiro Fujiwara

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Visualization, Writing – original draft, Writing – review & editing

y.fujiwara@iqb.u-tokyo.ac.jp

Affiliation Institute of Quantitative Biosciences, The University of Tokyo, Tokyo, Japan

Yuji Tanno

Roles Conceptualization, Methodology, Resources, Visualization, Writing – review & editing

Affiliation Bioscience Department, VERITAS Corporation, Tokyo, Japan

Hiroki Sugishita

Roles Investigation, Validation, Visualization, Writing – review & editing

Affiliation Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

Yusuke Kishi

Roles Investigation, Validation, Visualization, Writing – review & editing

Affiliation Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

Yoshinori Makino

Roles Conceptualization, Investigation, Methodology, Resources

Affiliation Institute of Quantitative Biosciences, The University of Tokyo, Tokyo, Japan

Yuki Okada

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Visualization, Writing – review & editing

Affiliation Institute of Quantitative Biosciences, The University of Tokyo, Tokyo, Japan

Competing Interests

The authors report that there were material support and technical advice from VERITAS corporation for this study that could have influenced its outcome and that one of the authors, Y.T. is its employee. This does not alter our adherence to PLOS ONE policies on sharing data and materials." We believe our revised manuscript would suffice the reviewer’s concerns. It would be greatly appreciated if the editorial office and reviewers could consider this revision. All the authors have read the manuscript and have approved this submission. All study participants provided informed consent, and the study design was approved by an ethics review board.