About the Authors

Stephan Ursprung

Contributed equally to this work with: Stephan Ursprung, Andrew N. Priest

Roles Formal analysis, Investigation, Visualization, Writing – original draft

Affiliations University of Cambridge, Cambridge, United Kingdom, Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom

Andrew N. Priest

Contributed equally to this work with: Stephan Ursprung, Andrew N. Priest

Roles Formal analysis, Investigation, Methodology, Software, Writing – review & editing

Affiliations University of Cambridge, Cambridge, United Kingdom, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom

Fulvio Zaccagna

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation University of Cambridge, Cambridge, United Kingdom

Wendi Qian

Roles Formal analysis, Validation, Visualization, Writing – review & editing

Affiliations University of Cambridge, Cambridge, United Kingdom, Cambridge Cancer Trial Centre, Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom

Andrea Machin

Roles Formal analysis, Validation, Visualization, Writing – review & editing

Affiliations University of Cambridge, Cambridge, United Kingdom, Cambridge Cancer Trial Centre, Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom

Grant D. Stewart

Roles Supervision, Writing – review & editing

Affiliations University of Cambridge, Cambridge, United Kingdom, Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom

Anne Y. Warren

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations University of Cambridge, Cambridge, United Kingdom, Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom

Timothy Eisen

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

Affiliations University of Cambridge, Cambridge, United Kingdom, Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom

Sarah J. Welsh

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

Affiliations University of Cambridge, Cambridge, United Kingdom, Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom

Ferdia A. Gallagher

Roles Supervision, Validation, Writing – review & editing

Affiliations University of Cambridge, Cambridge, United Kingdom, Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom

Tristan Barrett

Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Supervision, Writing – review & editing

tb507@cam.ac.uk

Affiliations University of Cambridge, Cambridge, United Kingdom, Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom

Competing Interests

The authors have read the journal’s policy and have the following competing interests: ANP has received a speaker fee and travel expenses from GE Healthcare. SJW has received travel expenses from IPSEN. GDS has received educational grants from Pfizer, Astra Zeneca, and Intuitive Surgical; consultancy fees from Merck, Pfizer, EUSA Pharma and CMR Surgical; travel expenses and speaker fees from Pfizer. AW received a single Scientific Advisory Board fee from Roche. TE has received research support from Pfizer and AstraZeneca, and honoraria from Pfizer. TE was employed by AstraZeneca during part of the study duration and is now employed by Roche, and holds stock in AstraZeneca and Roche. Pfizer provided the study drug Sunitinib and an educational grant for the translational endpoint analysis, reported separately. There are no patents, products in development or marketed products associated with this research to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials.