Upregulation of a nuclear factor-kappa B-interacting immune gene network in mice cochleae with age-related hearing loss

Kensuke Uraguchi; Yukihide Maeda; Junko Takahara; Ryotaro Omichi; Shohei Fujimoto; Shin Kariya; Kazunori Nishizaki; Mizuo Ando

doi:10.1371/journal.pone.0258977

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Open Access

Peer-reviewed

Research Article

Upregulation of a nuclear factor-kappa B-interacting immune gene network in mice cochleae with age-related hearing loss

Kensuke Uraguchi,

Roles Conceptualization, Investigation, Writing – original draft

Affiliation Department of Otolaryngology- Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Yukihide Maeda ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: yamayuki@cc.okayama-u.ac.jp

Affiliation Department of Otolaryngology- Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

https://orcid.org/0000-0002-8106-9055

⨯
Junko Takahara,

Roles Investigation

Affiliation Department of Otolaryngology- Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Ryotaro Omichi,

Roles Investigation

Affiliation Department of Otolaryngology- Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Shohei Fujimoto,

Roles Conceptualization, Funding acquisition, Investigation

Affiliation Department of Otolaryngology- Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Shin Kariya,

Roles Conceptualization, Funding acquisition

Affiliation Department of Otolaryngology- Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Kazunori Nishizaki,

Roles Resources, Supervision

Affiliation Department of Otolaryngology- Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Mizuo Ando

Roles Resources, Supervision, Writing – review & editing

Affiliation Department of Otolaryngology- Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯

Upregulation of a nuclear factor-kappa B-interacting immune gene network in mice cochleae with age-related hearing loss

Kensuke Uraguchi,
Yukihide Maeda,
Junko Takahara,
Ryotaro Omichi,
Shohei Fujimoto,
Shin Kariya,
Kazunori Nishizaki,
Mizuo Ando

Published: October 22, 2021
https://doi.org/10.1371/journal.pone.0258977

About the Authors

Kensuke Uraguchi

Roles Conceptualization, Investigation, Writing – original draft

Affiliation Department of Otolaryngology- Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

Yukihide Maeda

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: yamayuki@cc.okayama-u.ac.jp

Affiliation Department of Otolaryngology- Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

https://orcid.org/0000-0002-8106-9055

Junko Takahara

Roles Investigation

Affiliation Department of Otolaryngology- Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

Ryotaro Omichi

Roles Investigation

Affiliation Department of Otolaryngology- Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

Shohei Fujimoto

Roles Conceptualization, Funding acquisition, Investigation

Affiliation Department of Otolaryngology- Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

Shin Kariya

Roles Conceptualization, Funding acquisition

Affiliation Department of Otolaryngology- Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

Kazunori Nishizaki

Roles Resources, Supervision

Affiliation Department of Otolaryngology- Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

Mizuo Ando

Roles Resources, Supervision, Writing – review & editing

Affiliation Department of Otolaryngology- Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

Competing Interests

The authors have declared that no competing interests exist.

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Cochlea
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Inflammation
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Reverse transcriptase-polymerase chain reaction
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Gene expression
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Chemokines
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Toll-like receptors
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Transcription factors
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Ligaments
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