About the Authors

Kazuto Nakae

Contributed equally to this work with: Kazuto Nakae, Sho Masui

Roles Data curation, Formal analysis, Writing – original draft

Affiliations Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

Sho Masui

Contributed equally to this work with: Kazuto Nakae, Sho Masui

Roles Data curation, Formal analysis, Visualization, Writing – original draft

Affiliations Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

Atsushi Yonezawa

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

ayone@kuhp.kyoto-u.ac.jp

Affiliations Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

Motomu Hashimoto

Roles Conceptualization, Data curation, Resources, Supervision, Writing – review & editing

Affiliation Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Ryu Watanabe

Roles Data curation, Resources, Writing – review & editing

Affiliation Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Koichi Murata

Roles Conceptualization, Data curation, Resources, Writing – review & editing

Affiliation Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Kosaku Murakami

Roles Data curation, Resources, Writing – review & editing

Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Masao Tanaka

Roles Data curation, Resources, Writing – review & editing

Affiliation Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Hiromu Ito

Roles Data curation, Resources, Writing – review & editing

Affiliation Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Kotoko Yokoyama

Roles Methodology, Validation, Writing – review & editing

Affiliation Shimadzu Corporation, Kyoto, Japan

Noriko Iwamoto

Roles Methodology, Validation, Writing – review & editing

Affiliations Shimadzu Corporation, Kyoto, Japan, Shimadzu Scientific Instruments, Bothell, Washington, United States of America

Takashi Shimada

Roles Methodology, Supervision, Validation, Writing – review & editing

Affiliations Shimadzu Corporation, Kyoto, Japan, Shimadzu Scientific Instruments, Bothell, Washington, United States of America

Miyuki Nakamura

Roles Data curation, Formal analysis, Writing – original draft

Affiliations Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

Masaya Denda

Roles Data curation, Formal analysis, Writing – original draft

Affiliations Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

Kotaro Itohara

Roles Data curation, Writing – review & editing

Affiliation Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan

Shunsaku Nakagawa

Roles Data curation, Writing – review & editing

Affiliation Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan

Yasuaki Ikemi

Roles Data curation, Writing – review & editing

Affiliation Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan

Satoshi Imai

Roles Data curation, Supervision, Writing – review & editing

Affiliation Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan

Takayuki Nakagawa

Roles Data curation, Supervision, Writing – review & editing

Affiliation Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan

Makoto Hayakari

Roles Formal analysis, Supervision, Writing – review & editing

Affiliation Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan

Kazuo Matsubara

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan

Competing Interests

M.H., R.W., K.Murata, M.T., and H.I. are associated with a department financially supported by two local governments in Japan (Nagahama City, Shiga and Toyooka City, Hyogo) and five pharmaceutical companies (Mitsubishi Tanabe Pharma Corp., Chugai Pharmaceutical Co., Ltd., Ayumi Pharmaceutical Corp., Asahi Kasei Pharma Corp., and UCB Japan Co., Ltd.). A.Y. and K.Matsubara has received a research grant from Shimadzu Corporation. M.H. received a research grant and/or speaker fee from Bristol-Myers Squibb Co., Eisai Co., Ltd., Eli Lilly Japan K.K., and Mitsubishi Tanabe Pharma Corp. R.W. has received speaker’s fee from Mitsubishi Tanabe Pharma Corp., Pfizer Inc., Sanofi K.K., AbbVie GK, Asahi-Kasei Corp., Eisai Co., Ltd., Eli Lilly Japan K.K., Bristol-Myers Squibb Co., and Janssen Pharmaceutical K.K. K.Murata received a speaking fee from Eisai Co., Ltd., Mochida Pharmaceutical Co., Ltd., and Astellas Pharma Inc. M.T. has received research grants and/or speaker fees from AbbVie GK, Asahi Kasei Pharma Corp., Astellas Pharma Inc., Ayumi Pharmaceutical Corp., Chugai Pharmaceutical Co., Ltd., Eisai Co., Ltd., Eli Lilly Japan K.K., Janssen Pharmaceutical K.K., Mitsubishi Tanabe Pharma Corp., Novartis Pharma K.K., Pfizer Inc., Taisho Pharma Co., Ltd., and UCB Japan Co., Ltd. H.I. has received a research grant and/or speaker fees from Bristol-Myers Squibb Co., Eisai Co., Ltd., Taisho Pharmaceutical Co., Ltd., Mochida Pharmaceutical Co., Ltd., and Asahi Kasei Corp. The other authors declare no conflicts of interest.