About the Authors

Elizabeth C. Stahl

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft

Affiliations University of California, Berkeley, Berkeley, CA, United States of America, Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

Allan R. Gopez

Roles Data curation, Investigation, Methodology, Validation

Affiliation Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

Connor A. Tsuchida

Roles Data curation, Investigation, Writing – review & editing

Affiliations University of California, Berkeley, Berkeley, CA, United States of America, Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

Vinson B. Fan

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation University of California, Berkeley, Berkeley, CA, United States of America

Erica A. Moehle

Roles Formal analysis, Investigation, Project administration, Visualization, Writing – review & editing

Affiliations University of California, Berkeley, Berkeley, CA, United States of America, Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

Lea B. Witkowsky

Roles Project administration, Resources, Visualization, Writing – review & editing

Affiliations University of California, Berkeley, Berkeley, CA, United States of America, Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

Jennifer R. Hamilton

Roles Investigation, Methodology, Writing – review & editing

Affiliations University of California, Berkeley, Berkeley, CA, United States of America, Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

Enrique Lin-Shiao

Roles Investigation, Methodology, Writing – review & editing

Affiliations University of California, Berkeley, Berkeley, CA, United States of America, Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

Matthew McElroy

Roles Investigation, Methodology, Project administration, Writing – review & editing

Affiliation Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

Shana L. McDevitt

Roles Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

Affiliations University of California, Berkeley, Berkeley, CA, United States of America, Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

Alison Ciling

Roles Methodology, Project administration, Resources

Affiliations University of California, Berkeley, Berkeley, CA, United States of America, Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

C. Kimberly Tsui

Roles Investigation, Methodology

Affiliation University of California, Berkeley, Berkeley, CA, United States of America

Kathleen Pestal

Roles Supervision, Writing – review & editing

Affiliation University of California, Berkeley, Berkeley, CA, United States of America

Holly K. Gildea

Roles Resources, Supervision, Writing – review & editing

Affiliation University of California, Berkeley, Berkeley, CA, United States of America

Amanda Keller

Roles Data curation, Methodology

Affiliation Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

Iman A. Sylvain

Roles Data curation, Methodology, Project administration

Affiliation Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

Clara Williams

Roles Data curation, Methodology

Affiliation Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

Ariana Hirsh

Roles Project administration, Resources

Affiliations University of California, Berkeley, Berkeley, CA, United States of America, Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

Alexander J. Ehrenberg

Roles Project administration, Writing – review & editing

Affiliation University of California, Berkeley, Berkeley, CA, United States of America

Rose Kantor

Roles Conceptualization, Writing – review & editing

Affiliations University of California, Berkeley, Berkeley, CA, United States of America, Department of Civil and Environmental Engineering, University of California, Berkeley, CA, United States of America

Matthew Metzger

Roles Project administration, Resources

Affiliations University of California, Berkeley, Berkeley, CA, United States of America, Department of Civil and Environmental Engineering, University of California, Berkeley, CA, United States of America

Kara L. Nelson

Roles Investigation, Supervision, Writing – review & editing

Affiliations University of California, Berkeley, Berkeley, CA, United States of America, Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America, Department of Civil and Environmental Engineering, University of California, Berkeley, CA, United States of America

Fyodor D. Urnov

Roles Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliations University of California, Berkeley, Berkeley, CA, United States of America, Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

Bradley R. Ringeisen

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliations University of California, Berkeley, Berkeley, CA, United States of America, Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

Petros Giannikopoulos

Roles Formal analysis, Project administration, Supervision, Validation, Writing – review & editing

Affiliation Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America

Jennifer A. Doudna

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

doudna@berkeley.edu

Affiliations University of California, Berkeley, Berkeley, CA, United States of America, Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States of America, Howard Hughes Medical Institute, University of California, Berkeley, CA, United States of America

IGI Testing Consortium

Membership of The IGI Testing Consortium is provided in the Acknowledgments.

Competing Interests

The authors have read the journal’s policy and the authors of this manuscript have the following competing interests: The Regents of the University of California have patents issued and pending for CRISPR technologies on which J.A.D. is an inventor. J.A.D. is a cofounder of Caribou Biosciences, Editas Medicine, Scribe Therapeutics, Intellia Therapeutics and Mammoth Biosciences. J.A.D. is a scientific advisory board member of Caribou Biosciences, Intellia Therapeutics, eFFECTOR Therapeutics, Scribe Therapeutics, Mammoth Biosciences, Synthego, Algen Biotechnologies, Felix Biosciences and Inari. J.A.D. is a Director at Johnson & Johnson and has research projects sponsored by Biogen, Pfizer, AppleTree Partners and Roche. F.D.U. is a co-founder of Tune Therapeutics. P.G. is a cofounder and Director at NewCo Health. P.G. is the CLIA Laboratory Director for Coral Genomics and 3DMed. This does not alter our adherence to PLOS ONE policies on sharing data and materials.