About the Authors

Riho Tateyama-Makino

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

riho-t@lion.co.jp

‡ These authors have contributed equally to this work and share first authorship

Affiliation Research & Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan

Mari Abe-Yutori

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

‡ These authors have contributed equally to this work and share first authorship

Affiliation Research & Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan

Taku Iwamoto

Roles Conceptualization, Methodology, Visualization, Writing – original draft

Affiliation Research & Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan

Kota Tsutsumi

Roles Conceptualization, Methodology, Visualization, Writing – original draft

Affiliation Research & Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan

Motonori Tsuji

Roles Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

Affiliation Institute of Molecular Function, Misato-shi, Saitama, Japan

Satoru Morishita

Roles Conceptualization, Writing – review & editing

Affiliation Research & Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan

Kei Kurita

Roles Conceptualization, Writing – review & editing

Affiliation Research & Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan

Yukio Yamamoto

Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

Affiliation Research & Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan

Eiji Nishinaga

Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

Affiliation Research & Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan

Keiichi Tsukinoki

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Division of Environmental Pathology, Department of Oral Science, Kanagawa Dental University, Yokosuka, Kanagawa, Japan

Competing Interests

We have read the journal‘s policy and the authors of this manuscript have the following competing interests: R Tateyama-Makino, M Abe-Yutori, T Iwamoto, K Tsutsumi, S Morishita, K Kurita, Y Yamamoto, and E Nishinaga are employees of the Lion Corporation (Tokyo, Japan). M Tsuji is a President of the Institute of Molecular Function (Saitama, Japan). Molecular docking simulation was performed by the Institute of Molecular Function under a consignment from the Lion Corporation. K Tsukinoki has received fees for technical guidance from the Lion Corporation. This does not alter our adherence to PLOS ONE policies on sharing data and materials.