About the Authors

Katarzyna Bazydlo-Guzenda

Roles Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliations Innovative Drugs R&D Department, Celon Pharma S.A., Lomianki, Poland, Postgraduate School of Molecular Medicine, Warsaw, Poland

Pawel Buda

Roles Formal analysis, Funding acquisition, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

pawel.buda@celonpharma.com

Affiliation Innovative Drugs R&D Department, Celon Pharma S.A., Lomianki, Poland

Mateusz Mach

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Innovative Drugs R&D Department, Celon Pharma S.A., Lomianki, Poland

Jerzy Pieczykolan

Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

Affiliation Innovative Drugs R&D Department, Celon Pharma S.A., Lomianki, Poland

Izabela Kozlowska

Roles Methodology, Writing – review & editing

Affiliation Innovative Drugs R&D Department, Celon Pharma S.A., Lomianki, Poland

Michal Janiszewski

Roles Funding acquisition, Investigation, Writing – review & editing

Affiliation Innovative Drugs R&D Department, Celon Pharma S.A., Lomianki, Poland

Ewa Drzazga

Roles Investigation, Writing – review & editing

Affiliation Innovative Drugs R&D Department, Celon Pharma S.A., Lomianki, Poland

Jakub Dominowski

Roles Investigation, Visualization, Writing – review & editing

Affiliation Innovative Drugs R&D Department, Celon Pharma S.A., Lomianki, Poland

Hubert Ziolkowski

Roles Formal analysis, Writing – review & editing

Affiliation Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland

Maciej Wieczorek

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Writing – review & editing

Affiliation Innovative Drugs R&D Department, Celon Pharma S.A., Lomianki, Poland

Shayne Cox Gad

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing

Affiliation Gad Consulting Services, Raleigh, North Carolina Area, United States of America

Competing Interests

All authors declare no conflict of interest. The authors KB-G, PB, MM, JP, MJ, ED, IK, JD, MW were employees of Celon Pharma S.A. when the present study was conducted. SCG was employed by Gad Consulting Services and provided the external scientific expertise sat the stage of design and revision of the study. This does not alter our adherence to PLOS ONE policies on sharing data and materials.