About the Authors

Giovanni Staurenghi

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

giovanni.staurenghi@unimi.it

Affiliation Department of Biomedical and Clinical Sciences “Luigi Sacco”, Luigi Sacco Hospital, University of Milan, Milan, Italy

Francesco Bandello

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, Milan, Italy

Francesco Viola

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliation Foundation IRCCS Cà Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy

Monica Varano

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliation IRCCS-Fondazione Bietti, Rome, Italy

Giulia Barbati

Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Medical Sciences, Biostatistics Unit, University of Trieste, Trieste, Italy

Elena Peruzzi

Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation Novartis Farma S.p.A., Origgio, VA, Italy

Stefania Bassanini

Roles Conceptualization, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliation Novartis Farma S.p.A., Origgio, VA, Italy

Chiara Biancotto

Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation Novartis Farma S.p.A., Origgio, VA, Italy

Vito Fenicia

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliation Faculty of Medicine and Psychology, NESMOS Department, Ophthalmology Unit, S. Andrea Hospital, University of Rome "La Sapienza", Rome, Italy

Claudio Furino

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Medical Science, Neuroscience and Sense Organs, Eye Clinic, Azienda Ospedaliero-Universitaria Policlinico Consorziale Bari, Bari, Italy

Maria Vadalà

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliation Biomedicine, Neuroscience and Advanced Diagnostic Department, Unit of Ophthalmology, University of Palermo, Palermo, Italy

Michele Reibaldi

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Surgical Sciences, University of Torino, Turin, Italy

Stela Vujosevic

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliation Eye Clinic, IRCCS MultiMedica, Milan, Italy

Federico Ricci

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department Experimental Medicine, Tor Vergata University, Viale Oxford, Roma, Italy

on behalf of the EAGLE study investigators

The details of EAGLE study principal investigators is provided in Acknowledgments.

Competing Interests

Giovanni Staurenghi: Heidelberg Engineering1,2,3, Optos2, Ocular Instruments4, Optovue2, Quantel Medical2, Centervue1,2, Carl Zeiss Meditec2, Nidek2,3, Apellis1, Allergan1, Astellas1, Bayer1,3, Boheringer1, Topcon2, Genentech1, Iveric1, Novartis1,3, Roche1,3, Chengdu Kanghong Biotechnology Co1, Kyoto Drug Discovery & Development Co1. 1 consultant/advisor, 2 grant support, 3 lecture fee, 4 patents/royalty Francesco Bandello: Advisory for Allergan, Bayer, Boehringer-Ingelheim, Fidia Sooft, Hofmann La Roche, Novartis, NTC Pharma, Sifi, Thrombogenics and Zeiss Francesco Viola: Advisor for Allergan, Bayer, Novartis Farma S.p.A., and Roche. Monica Varano: Advisory board participation for Allergan, Bayer, Biogen, and Novartis Farma S.p.A. Giulia Barbati: Statistical consultant and received funding from Novartis. Elena Peruzzi, Stefania Bassanini and Chiara Biancotto: Employees of Novartis Farma S.p.A., Origgio, Italy. Vito Fenicia: Nothing to declare Claudio Furino: Advisory board participation for Allergan and Bayer Maria Vadalà: Advisor for Allergan Italia S.p.A., Bayer Italia S.p.A., and Novartis Farma S.p.A. Michele Reibaldi: Advisor for Allergan, Bayer, Novartis and SIFI. Stela Vujosevic: Advisory Board participation for Allergan, Apellis, Bayer, and Novartis. Federico Ricci: Advisor for Allergan, Bayer, Biogen, Genetech, MS&D, Novartis, Regeneron, and Roche. This aforementioned disclosures/ commercial affiliations of the authors does not alter our adherence to PLOS ONE policies on sharing data and materials.