About the Authors

Azzurra Sargenti

Contributed equally to this work with: Azzurra Sargenti, Francesco Musmeci, Carola Cavallo

Roles Data curation, Investigation, Validation, Writing – original draft

Affiliation Cell Dynamics iSRL, Bologna, Italy

Francesco Musmeci

Contributed equally to this work with: Azzurra Sargenti, Francesco Musmeci, Carola Cavallo

Roles Data curation, Formal analysis, Validation

Affiliation Cell Dynamics iSRL, Bologna, Italy

Carola Cavallo

Contributed equally to this work with: Azzurra Sargenti, Francesco Musmeci, Carola Cavallo

Roles Conceptualization, Data curation, Investigation, Validation

Affiliation RAMSES Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

Martina Mazzeschi

Roles Formal analysis

Affiliation Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy

Simone Bonetti

Roles Methodology, Software

Affiliation Cell Dynamics iSRL, Bologna, Italy

Simone Pasqua

Roles Funding acquisition, Supervision

Affiliation Cell Dynamics iSRL, Bologna, Italy

Francesco Bacchi

Roles Data curation, Visualization

Affiliation Cell Dynamics iSRL, Bologna, Italy

Giuseppe Filardo

Roles Writing – original draft, Writing – review & editing

Affiliation Applied and Translational Research Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

Daniele Gazzola

Roles Funding acquisition, Software

Affiliation Cell Dynamics iSRL, Bologna, Italy

Mattia Lauriola

Roles Supervision, Validation, Writing – review & editing

Affiliation Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy

Spartaco Santi

Roles Conceptualization, Project administration, Writing – review & editing

spartaco.santi@cnt.it

Affiliations Institute of Molecular Genetics “Luigi Luca Cavalli-Sforza”, Unit of Bologna, CNR, Bologna, Italy, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

Competing Interests

The authors of Affiliation 1 (AS, FM, SB, SP, FB and DG) are employed by Cell Dynamics iSRL company. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The remaining authors (CC, MM, GF, ML and SS) declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare that a Patent Application (No. 102020000006031) incorporating parts of this work has been filed. This does not alter our adherence to PLOS ONE policies on sharing data and materials. Daniele Gazzola, Simone Bonetti, Domenico Andrea Cristaldi, Azzurra Sargenti and Francesco Musmeci are the inventors of patent No. 102020000006031.