About the Authors

Sang-Yun Lee

Roles Conceptualization, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliations Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea, Central R & D Center, Medical & Bio Device (MBD) Co., Ltd, Suwon, Republic of Korea

Yvonne Teng

Roles Writing – original draft, Writing – review & editing

Affiliation Research & Development Department, AVATAMED Pte. Ltd., Singapore, Singapore

Miseol Son

Roles Writing – original draft, Writing – review & editing

Affiliation Research & Development Department, AVATAMED Pte. Ltd., Singapore, Singapore

Bosung Ku

Roles Methodology

Affiliation Central R & D Center, Medical & Bio Device (MBD) Co., Ltd, Suwon, Republic of Korea

Ho Sang Moon

Roles Methodology

Affiliation Central R & D Center, Medical & Bio Device (MBD) Co., Ltd, Suwon, Republic of Korea

Vinay Tergaonkar

Roles Writing – review & editing

Affiliations Laboratory of NFκB Signaling, Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore, Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore

Pierce Kah-Hoe Chow

Roles Writing – review & editing

Affiliations Division of Surgery and Surgical Oncology, National Cancer Centre Singapore (NCCS), Singapore, Singapore, Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital (SGH), Singapore, Singapore, Surgery Academic Clinical Programme, Duke-NUS Medical School, Singapore, Singapore, Faculty (Senior Group Leader), Genome Institute of Singapore (GIS), Singapore, Singapore, Research Director, Institute of Molecular Cell Biology (IMCB), Singapore, Singapore

Dong Woo Lee

Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

dw2010.lee@gmail.com (DWL); nsnam@skku.edu (DHN)

Affiliation Department of Biomedical Engineering, Konyang University, Daejon, Korea

Do-Hyun Nam

Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

dw2010.lee@gmail.com (DWL); nsnam@skku.edu (DHN)

Affiliations Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea, Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Competing Interests

Regarding Medical & Bio Device (MBD) Co., Ltd., Company provided 3D cell culture chip for research. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials. Regarding AVATAMED Pte. Ltd., Company provided 3D cell analysis for research. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.