About the Authors

Laura Orsatti

Roles Conceptualization, Data curation, Methodology, Writing – original draft

e.monteagudo@irbm.com (EM); l.orsatti@irbm.com (LO)

Affiliation ADME/DMPK Department, IRBM SpA, Pomezia, Roma, Italy

Maria Vittoria Orsale

Contributed equally to this work with: Maria Vittoria Orsale, Pamela di Pasquale, Andrea Vecchi

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation ADME/DMPK Department, IRBM SpA, Pomezia, Roma, Italy

Pamela di Pasquale

Contributed equally to this work with: Maria Vittoria Orsale, Pamela di Pasquale, Andrea Vecchi

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation ADME/DMPK Department, IRBM SpA, Pomezia, Roma, Italy

Andrea Vecchi

Contributed equally to this work with: Maria Vittoria Orsale, Pamela di Pasquale, Andrea Vecchi

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Current address: Birra Peroni, Roma, Italy

Affiliation ADME/DMPK Department, IRBM SpA, Pomezia, Roma, Italy

Fabrizio Colaceci

Roles Formal analysis

Affiliation ADME/DMPK Department, IRBM SpA, Pomezia, Roma, Italy

Alina Ciammaichella

Roles Formal analysis

Affiliation Medicinal Chemistry Department, IRBM SpA, Pomezia, Roma, Italy

Ilaria Rossetti

Roles Formal analysis

Affiliation Medicinal Chemistry Department, IRBM SpA, Pomezia, Roma, Italy

Fabio Bonelli

Roles Data curation, Methodology

Affiliation ADME/DMPK Department, IRBM SpA, Pomezia, Roma, Italy

Karsten Baumgaertel

Roles Data curation, Formal analysis

Affiliation Retrophin, San Diego, CA, United States of America

Kai Liu

Roles Conceptualization, Data curation, Methodology

Affiliation Retrophin, San Diego, CA, United States of America

Daniel Elbaum

Roles Conceptualization

Current address: QurAlis, Cambridge, MA, United States of America

Affiliation Retrophin, San Diego, CA, United States of America

Edith Monteagudo

Roles Conceptualization, Writing – original draft

e.monteagudo@irbm.com (EM); l.orsatti@irbm.com (LO)

Affiliation ADME/DMPK Department, IRBM SpA, Pomezia, Roma, Italy

Competing Interests

Kai Liu and Karsten Baumgaertel are employees of Retrophin, Inc. Daniel Elbaum was employee of Retrophin, Inc. during his work on this project. Laura Orsatti, Edith Monteagudo, Maria Vittoria Orsale, Pamela di Pasquale, Fabrizio Colaceci, Alina Ciammaichella, Ilaria Rossetti and Fabio Bonelli are employees of IRBM working under contract to Retrophin, Inc. Andrea Vecchi was employee of IRBM working under contract to Retrophin, Inc during his work on this project. The authors who are current and former Retrophin employees may have an equity or other financial interest in Retrophin. This does not alter our adherence to PLOS ONE policies on sharing data and materials.