https://orcid.org/0000-0002-7745-2844
About the Authors
- Liora Haim-Vilmovsky
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Contributed equally to this work with: Liora Haim-Vilmovsky, Johan Henriksson
Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliations EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
- Johan Henriksson
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Contributed equally to this work with: Liora Haim-Vilmovsky, Johan Henriksson
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing
Current address: Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden; Department of Molecular Biology, Umeå University, Umeå, Sweden
Affiliations EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
- Jennifer A. Walker
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Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Writing – original draft
Affiliation MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, United Kingdom
- Zhichao Miao
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Roles Formal analysis
Affiliations EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
- Eviatar Natan
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Roles Data curation, Investigation, Validation
Current address: The Aleph Lab, Oxford, United Kingdom
Affiliation EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
- Gozde Kar
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Roles Formal analysis
Current address: Translational Medicine, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, United Kingdom
Affiliations EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
- Simon Clare
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Roles Investigation
Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
- Jillian L. Barlow
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Roles Investigation, Validation
Current address: Department of Biology, University of York, Wentworth Way, York, United Kingdom
Affiliation MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, United Kingdom
- Evelina Charidemou
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Roles Investigation
Affiliation Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
- Lira Mamanova
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Roles Investigation
Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
- Xi Chen
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Roles Investigation
Current address: Department of Biology, South University of Science and Technology of China, Shenzhen, China
Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
- Valentina Proserpio
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Roles Investigation, Writing – review & editing
Current address: IIGM Foundation–Italian Institute for Genomic Medicine, Candiolo, Torino, Italy; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Torino, Italy
Affiliations EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
- Jhuma Pramanik
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Roles Investigation
Current address: Department of Pathology, University of Cambridge, Cambridge, United Kingdom
Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
- Steven Woodhouse
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Roles Formal analysis
Current address: Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Affiliations Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom, Wellcome Trust—Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
- Anna V. Protasio
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Roles Investigation
Current address: Department of Pathology, University of Cambridge, Cambridge, United Kingdom
Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
- Mirjana Efremova
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Roles Formal analysis
Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
- Julian L. Griffin
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Roles Resources
Affiliations Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom, Department of Metabolism, Digestion and Reproduction, Biomolecular Medicine, Imperial College London, London, United Kingdom
- Matt Berriman
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Roles Resources
Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
- Gordon Dougan
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Roles Resources
Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
- Jasmin Fisher
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Roles Resources, Supervision
Current address: UCL Cancer Institute, University College London, London, United Kingdom
Affiliation Microsoft Research, Cambridge, United Kingdom
- John C. Marioni
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Roles Conceptualization, Resources, Supervision, Writing – original draft
Affiliations EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom
- Andrew N. J. McKenzie
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Roles Conceptualization, Resources, Supervision, Writing – original draft, Writing – review & editing
Affiliation MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, United Kingdom
- Sarah A. Teichmann
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Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft
* E-mail: st9@sanger.ac.uk
Affiliations EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Theory of Condensed Matter, Cavendish Laboratory, Cambridge, United Kingdom
Competing Interests
The authors have read the journal’s policy and have the following competing interests: JF was an employee of Microsoft Research Cambridge at the time the study was conducted, but is no longer an employee of the company. EN is an employee of Aleph Labs, but was not employed by the company at the time the study was conducted. GK is an employee of AstraZeneca, but was not employed by the company at the time the study was conducted. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products associated with this research to declare.