About the Authors

Mauro Contini

Contributed equally to this work with: Mauro Contini, Antonio Sarmento

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Centro Cardiologico Monzino, IRCCS, Milano, Italy

Antonio Sarmento

Contributed equally to this work with: Mauro Contini, Antonio Sarmento

Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, Italy

Paola Gugliandolo

Roles Conceptualization, Data curation, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Centro Cardiologico Monzino, IRCCS, Milano, Italy

Alessandra Leonardi

Roles Data curation, Formal analysis, Investigation, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation L.I.F.E. Corporation S.A., Luxembourg, Luxembourg

Gianluigi Longinotti-Buitoni

Roles Conceptualization, Data curation, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation L.I.F.E. Corporation S.A., Luxembourg, Luxembourg

Camilla Minella

Roles Data curation, Formal analysis, Investigation, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation L.I.F.E. Italia S.r.l., Milano, Italy

Carlo Vignati

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Centro Cardiologico Monzino, IRCCS, Milano, Italy, Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milano, Milano, Italy

Massimo Mapelli

Roles Data curation, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Centro Cardiologico Monzino, IRCCS, Milano, Italy

Andrea Aliverti

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

andrea.aliverti@polimi.it

Affiliation Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, Italy

Piergiuseppe Agostoni

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Centro Cardiologico Monzino, IRCCS, Milano, Italy, Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milano, Milano, Italy

Competing Interests

Dr. Longinotti-Buitoni and Dr. Aliverti are inventors in patents related to the submitted work (Patents number US20200323285, US20200068708, US20180376586, US20180184735, US9282893). Dr. Aliverti received consultancy fees from L.I.F.E. Corporation S.A. outside the submitted work. Dr. Agostoni has non-financial support from Menarini, grants from Daiichi Sankyo, nonfinancial support from Novartis, non-financial support from Boeringer, grants and nonfinancial support from Actelion, and grants from Bayer, outside the work presented in this article. This does not alter the adherence to PLOS ONE policies on sharing data and materials.