About the Authors

Steven A. Saenz

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

steven.saenz@bms.com (SAS); michael.ellis@bms.com (JME)

Affiliation Immunology, Cardiovascular & Fibrosis, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America

Andrea Local

Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, California, United States of America

Tiffany Carr

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft

Affiliation Immunology, Cardiovascular & Fibrosis, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America

Arvind Shakya

Roles Data curation, Formal analysis

Affiliation Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, California, United States of America

Shivsmriti Koul

Roles Data curation, Formal analysis

Affiliation Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, California, United States of America

Haiqing Hu

Roles Data curation, Formal analysis

Affiliation Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America

Lisa Chourb

Roles Data curation, Formal analysis

Affiliation Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America

Justin Stedman

Roles Data curation, Formal analysis

Affiliation Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America

Jenna Malley

Roles Formal analysis

Current address: Takeda Pharmaceuticals, Cambridge, Massachusetts, United States of America

Affiliation Nonclinical Development, Celgene Corporation, Cambridge, Massachusetts, United States of America

Laura Akullian D’Agostino

Roles Data curation, Formal analysis, Supervision, Visualization, Writing – original draft

Affiliation Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America

Veerabahu Shanmugasundaram

Roles Visualization

Affiliation Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America

John Malona

Roles Formal analysis

Current address: Jnana Therapeutics, Boston, Massachusetts, United States of America

Affiliation Drug Substance Development, Bristol Myers Squibb, Summit, New Jersey, United States of America

C. Eric Schwartz

Roles Formal analysis, Supervision

Current address: Cedilla Therapeutics, Cambridge, Massachusetts, United States of America

Affiliation Drug Substance Development, Bristol Myers Squibb, Summit, New Jersey, United States of America

Lisa Beebe

Roles Conceptualization, Data curation, Supervision

Affiliation Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America

Meghan Clements

Roles Conceptualization, Data curation, Formal analysis

Current address: AbbVie, Worcester, Massachusetts, United States of America

Affiliation Nonclinical Development, Celgene Corporation, Cambridge, Massachusetts, United States of America

Ganesh Rajaraman

Roles Supervision

Current address: Novartis Pharmaceuticals, Cambridge, Massachusetts, United States of America

Affiliation Nonclinical Development, Celgene Corporation, Cambridge, Massachusetts, United States of America

John Cho

Roles Supervision

Current address: KSQ Therapeutics, Cambridge, Massachusetts, United States of America

Affiliation Immunology & Inflammation, Celgene Corporation, Cambridge, Massachusetts, United States of America

Lan Jiang

Roles Formal analysis

Affiliation Immunology, Cardiovascular & Fibrosis, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America

Alex Dubrovskiy

Roles Formal analysis

Affiliation Immunology, Cardiovascular & Fibrosis, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America

Matt Kreilein

Roles Formal analysis, Supervision

Affiliation Drug Substance Development, Bristol Myers Squibb, Summit, New Jersey, United States of America

Roman Shimanovich

Roles Formal analysis, Supervision

Affiliation Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America

Lawrence G. Hamann

Roles Supervision

Current address: Takeda Pharmaceuticals, Cambridge, Massachusetts, United States of America

Affiliation Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America

Laure Escoubet

Roles Data curation, Supervision, Writing – original draft

Affiliation Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, California, United States of America

J. Michael Ellis

Roles Conceptualization, Supervision, Writing – original draft

steven.saenz@bms.com (SAS); michael.ellis@bms.com (JME)

Affiliation Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America

Competing Interests

All authors are either present or former employees of Celgene Corporation and/or Bristol Myers Squibb and own stocks and/or shares of Bristol Myers Squibb. All work for the current study was performed by authors only while employed at Celgene Corporation or Bristol Myers Squibb. Celgene Corporation is a wholly owned subsidiary of Bristol Myers Squibb. The Bristol Myers Squibb was the sole funder for this study and provided support in the form of salaries for all authors, but did not have any additional role in the study design, data collection, analysis, decision to publish, or preparation of the manuscript. Jenna Malley & Lawrence G. Hamann are currently employed by Takeda Pharmaceuticals. John Malona is currently employed by Jnana Therapeutics. C. Eric Schwartz is currently employed by Cedilla Therapeutics. Meghan Clements is currently employed by AbbVie. Ganesh Rajaraman is currently employed by Novartis Pharmaceuticals. John Cho is currently employed by KSQ Therapeutics. Neither Takeda Pharmaceuticals, Jnana Therapeutics, Cedilla Therapeutics, AbbVie, Novartis Pharmaceuticals or KSQ Therapeutics provided funding to the current work and these affiliations do not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.