About the Authors

Roxana Khatib Shahidi

Roles Formal analysis, Writing – original draft

Affiliation The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Jenny M. Hoffmann

Roles Formal analysis, Writing – original draft

Affiliation The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Shahram Hedjazifar

Roles Formal analysis, Writing – original draft

Affiliation The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Laurianne Bonnet

Roles Formal analysis, Writing – original draft

Affiliations The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Wallenberg Center for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden

Ritesh K. Baboota

Roles Formal analysis, Writing – original draft

Affiliation The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Stephanie Heasman

Roles Formal analysis, Writing – original draft

Affiliation Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom

Christopher Church

Roles Formal analysis, Writing – original draft

Affiliation Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom

Ivet Elias

Roles Methodology

Affiliation Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra and Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)

Fatima Bosch

Roles Methodology

Affiliation Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra and Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)

Jeremie Boucher

Roles Supervision, Writing – original draft

Affiliations The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Wallenberg Center for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden, Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

Ann Hammarstedt

Roles Formal analysis, Writing – original draft

Affiliation The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Ulf Smith

Roles Conceptualization, Validation, Writing – original draft, Writing – review & editing

ulf.smith@medic.gu.se

Affiliation The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Competing Interests

All authors declare that they have no competing interests and that the funding of SH, CC and JB by Astra Zeneca only relates to funding these salaries. Furthermore, this funding does not alter our adherence to PLOS ONE policies on sharing data and materials.