About the Authors

Luis Quintairos

Contributed equally to this work with: Luis Quintairos, Helena Colom

Roles Formal analysis, Methodology, Writing – original draft

Affiliations Faculty of Pharmacy and Food Sciences, Biopharmaceutics and Pharmacokinetics Unit, Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, University of Barcelona, Barcelona, Spain, Pharmacology and Toxicology Laboratory, Biochemistry and Molecular Genetics, Biomedical Diagnostic Center (CDB), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain

Helena Colom

Contributed equally to this work with: Luis Quintairos, Helena Colom

Roles Conceptualization, Methodology, Supervision, Writing – original draft

helena.colom@ub.edu

Affiliation Faculty of Pharmacy and Food Sciences, Biopharmaceutics and Pharmacokinetics Unit, Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, University of Barcelona, Barcelona, Spain

Olga Millán

Roles Investigation, Writing – review & editing

Affiliations Pharmacology and Toxicology Laboratory, Biochemistry and Molecular Genetics, Biomedical Diagnostic Center (CDB), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain, Biomedical Research Center in Hepatic and Digestive Diseases (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain

Virginia Fortuna

Roles Investigation

Affiliation Pharmacology and Toxicology Laboratory, Biochemistry and Molecular Genetics, Biomedical Diagnostic Center (CDB), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain

Cristina Espinosa

Roles Investigation

Affiliation Pharmacology and Toxicology Laboratory, Biochemistry and Molecular Genetics, Biomedical Diagnostic Center (CDB), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain

Lluis Guirado

Roles Project administration, Resources

Affiliation Renal Transplant Unit, Nephrology Department, Fundació Puigvert, Barcelona, Spain

Klemens Budde

Roles Project administration, Resources

Affiliation Medizinische Klinik mit Schwerpunkt Nephrologie, Charité Universitätsmedizin Berlin, Berlin, Germany

Claudia Sommerer

Roles Project administration, Resources

Affiliation Department of Nephrology, University of Heidelberg, University Hospital of Heidelberg and Mannheim, Heidelberg, Germany

Ana Lizana

Roles Investigation

Affiliation Pharmacology and Toxicology Laboratory, Biochemistry and Molecular Genetics, Biomedical Diagnostic Center (CDB), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain

Yolanda López-Púa

Roles Validation

Affiliation Quality Unit of CDB, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain

Mercè Brunet

Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Pharmacology and Toxicology Laboratory, Biochemistry and Molecular Genetics, Biomedical Diagnostic Center (CDB), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain, Biomedical Research Center in Hepatic and Digestive Diseases (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain

Competing Interests

This work was funded by TEVA Pharmaceuticals, a commercial company. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, marketed products or products in development associated with this research. Fundació Clínic per la Recerca Biomèdica (FCRB) (Research Center of Hospital Clínic of Barcelona) acted as promoter of the study and was responsible for starting and managing of the study, but did not provide financial support.