About the Authors

Antonietta Mele

Contributed equally to this work with: Antonietta Mele, Paola Mantuano

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Section of Pharmacology, Department of Pharmacy—Drug Sciences, University of Bari "Aldo Moro", Bari, Italy

Paola Mantuano

Contributed equally to this work with: Antonietta Mele, Paola Mantuano

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Section of Pharmacology, Department of Pharmacy—Drug Sciences, University of Bari "Aldo Moro", Bari, Italy

Adriano Fonzino

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Section of Pharmacology, Department of Pharmacy—Drug Sciences, University of Bari "Aldo Moro", Bari, Italy

Francesco Rana

Roles Formal analysis, Investigation, Methodology

Affiliation Section of Pharmacology, Department of Pharmacy—Drug Sciences, University of Bari "Aldo Moro", Bari, Italy

Roberta Francesca Capogrosso

Roles Formal analysis, Investigation

Affiliation Section of Pharmacology, Department of Pharmacy—Drug Sciences, University of Bari "Aldo Moro", Bari, Italy

Francesca Sanarica

Roles Formal analysis, Investigation, Validation

Affiliation Section of Pharmacology, Department of Pharmacy—Drug Sciences, University of Bari "Aldo Moro", Bari, Italy

Jean-Francois Rolland

Roles Supervision, Writing – review & editing

Affiliation Axxam, S.p.A, Bresso, Milan, Italy

Ornella Cappellari

Roles Investigation, Visualization

Affiliation Section of Pharmacology, Department of Pharmacy—Drug Sciences, University of Bari "Aldo Moro", Bari, Italy

Annamaria De Luca

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

annamaria.deluca@uniba.it

Affiliation Section of Pharmacology, Department of Pharmacy—Drug Sciences, University of Bari "Aldo Moro", Bari, Italy

Competing Interests

The authors declare no conflict of interest and confirm that the commercial affiliation with Axxam S.p.A. does not alter our adherence to PLOS ONE policies on sharing data and materials.