About the Authors

Fabio Quaglia

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA, United States of America, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States of America

Shiv Ram Krishn

Roles Investigation

Affiliations Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA, United States of America, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States of America

Yanqing Wang

Roles Data curation, Investigation, Resources

Affiliation Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States of America

David W. Goodrich

Roles Formal analysis, Funding acquisition, Resources, Writing – review & editing

Affiliation Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States of America

Peter McCue

Roles Formal analysis, Validation

Affiliation Department of Pathology, Thomas Jefferson University, Philadelphia, PA, United States of America

Andrew V. Kossenkov

Roles Formal analysis, Validation, Writing – review & editing

Affiliation Center for Systems and Computational Biology, Wistar Institute, Philadelphia, PA, United States of America

Amy C. Mandigo

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States of America

Karen E. Knudsen

Roles Formal analysis, Funding acquisition, Writing – review & editing

Affiliation Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States of America

Paul H. Weinreb

Roles Resources

Affiliation Biogen Inc., Cambridge, MA, United States of America

Eva Corey

Roles Resources

Affiliation Department of Urology, University of Washington, Seattle, Washington, United States of America

William K. Kelly

Roles Supervision

Affiliation Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, United States of America

Lucia R. Languino

Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Writing – original draft

lucia.languino@jefferson.edu

Affiliations Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA, United States of America, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States of America

Competing Interests

The authors of this study have read the journal’s policy and have the following competing interests: PW is an employee and a shareholder of Biogen Inc. Biogen holds patents covering avb6 antibodies and their uses for therapeutic purposes. However, this paper does not deal with the use of these antibodies for therapeutic purposes; these antibodies have been used just for immunoblotting in Fig 5. This does not alter our adherence to PLOS ONE policies on sharing data and materials.