About the Authors

Masaki Shoji

Roles Conceptualization, Funding acquisition, Investigation, Writing – original draft

masaki-shoji@ph.bunri-u.ac.jp (MS); kuzuhara@ph.bunri-u.ac.jp (TK)

Affiliation Faculty of Pharmaceutical Sciences, Laboratory of Biochemistry, Tokushima Bunri University, Yamashiro-cho, Tokushima, Japan

Minami Sugimoto

Roles Investigation

Affiliation Faculty of Pharmaceutical Sciences, Laboratory of Biochemistry, Tokushima Bunri University, Yamashiro-cho, Tokushima, Japan

Kosuke Matsuno

Roles Resources

Affiliation Yushin Brewer Co. Ltd., Ono, Ayagawa-cho, Ayauta-gun, Kagawa, Japan

Yoko Fujita

Roles Investigation

Affiliations Laboratory of Ultrastructural Virology, Graduate School of Biostudies, Kyoto University, Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Japan, Laboratory of Ultrastructural Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Japan

Tomohiro Mii

Roles Resources

Affiliation Yushin Brewer Co. Ltd., Ono, Ayagawa-cho, Ayauta-gun, Kagawa, Japan

Satomi Ayaki

Roles Resources

Affiliation Yushin Brewer Co. Ltd., Ono, Ayagawa-cho, Ayauta-gun, Kagawa, Japan

Misa Takeuchi

Roles Investigation

Affiliation Faculty of Pharmaceutical Sciences, Laboratory of Biochemistry, Tokushima Bunri University, Yamashiro-cho, Tokushima, Japan

Saki Yamaji

Roles Investigation

Affiliation Faculty of Pharmaceutical Sciences, Laboratory of Biochemistry, Tokushima Bunri University, Yamashiro-cho, Tokushima, Japan

Narue Tanaka

Roles Investigation

Affiliation Faculty of Pharmaceutical Sciences, Laboratory of Biochemistry, Tokushima Bunri University, Yamashiro-cho, Tokushima, Japan

Etsuhisa Takahashi

Roles Resources

Affiliation Division of Pathology and Metabolome Research for Infectious Disease and Host Defense, Institute for Enzyme Research, University of Tokushima, Kuramoto-cho, Tokushima, Japan

Takeshi Noda

Roles Investigation

Affiliations Laboratory of Ultrastructural Virology, Graduate School of Biostudies, Kyoto University, Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Japan, Laboratory of Ultrastructural Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Japan

Hiroshi Kido

Roles Resources

Affiliation Division of Pathology and Metabolome Research for Infectious Disease and Host Defense, Institute for Enzyme Research, University of Tokushima, Kuramoto-cho, Tokushima, Japan

Takaaki Tokuyama

Roles Resources

Affiliation Yushin Brewer Co. Ltd., Ono, Ayagawa-cho, Ayauta-gun, Kagawa, Japan

Takahito Tokuyama

Roles Resources

Affiliation Yushin Brewer Co. Ltd., Ono, Ayagawa-cho, Ayauta-gun, Kagawa, Japan

Takashi Tokuyama

Roles Resources

Affiliation Yushin Brewer Co. Ltd., Ono, Ayagawa-cho, Ayauta-gun, Kagawa, Japan

Takashi Kuzuhara

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

masaki-shoji@ph.bunri-u.ac.jp (MS); kuzuhara@ph.bunri-u.ac.jp (TK)

Affiliation Faculty of Pharmaceutical Sciences, Laboratory of Biochemistry, Tokushima Bunri University, Yamashiro-cho, Tokushima, Japan

Competing Interests

Research grant and Y30 extract were provided by the Yushin Brewer Co. Ltd. We declare that these relationships did not affect the results and conclusions of this manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials.