About the Authors

Andrew Piscitello

Roles Conceptualization, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

ajpiscitello@gmail.com

Affiliation EmpiriQA, LLC, Long Grove, IL, United States of America

Leila Saoud

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – review & editing

Affiliation Exact Sciences Corporation, Madison, WI, United States of America

A. Mark Fendrick

Roles Methodology, Writing – review & editing

Affiliation Division of Gastroenterology, University of Michigan, Ann Arbor, MI, United States of America

Bijan J. Borah

Roles Conceptualization, Writing – review & editing

Affiliation Department of Health Services Research, Mayo Clinic, Rochester, MN, United States of America

Kristen Hassmiller Lich

Roles Conceptualization, Writing – review & editing

Affiliation Department of Health Policy & Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America

Michael Matney

Roles Resources, Software, Writing – review & editing

Affiliation Exact Sciences Corporation, Madison, WI, United States of America

A. Burak Ozbay

Roles Conceptualization, Methodology, Supervision, Visualization, Writing – review & editing

Affiliation Exact Sciences Corporation, Madison, WI, United States of America

Marcus Parton

Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

Affiliation Exact Sciences Corporation, Madison, WI, United States of America

Paul J. Limburg

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States of America

Competing Interests

AP received compensation from Exact Sciences through a consulting agreement with Exact Sciences and EmpiriQA, LLC. LS, MM, ABO, and MP are employees of the study sponsor and received a salary. PJL serves as Chief Medical Officer for Screening at Exact Sciences through a contracted services agreement with Mayo Clinic. PJL and Mayo Clinic have contractual rights to receive royalties through this agreement. AMF has been a consultant for AbbVie, Amgen, Centivo, Community Oncology Association, Covered California, EmblemHealth, Exact Sciences, Freedman Health, GRAIL, Harvard University, Health & Wellness Innovations, Health at Scale Technologies, MedZed, Penguin Pay, Risalto, Sempre Health, the State of Minnesota, U.S. Department of Defense, Virginia Center for Health Innovation, Wellth, and Zansors; has received research support from the Agency for Healthcare Research and Quality, Gary and Mary West Health Policy Center, Arnold Ventures, National Pharmaceutical Council, Patient-Centered Outcomes Research Institute, Pharmaceutical Research and Manufacturers of America, the Robert Wood Johnson Foundation, the State of Michigan, and the Centers for Medicare and Medicaid Services. BJB has nothing to disclose. KHL has nothing to disclose. The authors would like to declare the following patents/patent applications associated with this research: Exact Sciences is the manufacturer of a marketed mt-sDNA test, Cologuard. This does not alter our adherence to PLOS ONE policies on sharing data and materials.