About the Authors

Mohammadreza Khani

Roles Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Chemical and Biological Engineering, University of Idaho, Moscow, ID, United States of America, Alcyone Therapeutics, Lowell, MA, United States of America

Audrey Q. Fu

Roles Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Statistical Science, University of Idaho, Moscow, ID, United States of America

Joshua Pluid

Roles Methodology, Writing – original draft

Affiliation Department of Chemical and Biological Engineering, University of Idaho, Moscow, ID, United States of America

Christina P. Gibbs

Roles Methodology, Writing – original draft

Affiliation Department of Chemical and Biological Engineering, University of Idaho, Moscow, ID, United States of America

John N. Oshinski

Roles Data curation, Writing – original draft, Writing – review & editing

Affiliation Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States of America

Tao Xing

Roles Methodology, Writing – review & editing

Affiliation Department of Mechanical Engineering, University of Idaho, Moscow, ID, United States of America

Gregory R. Stewart

Roles Conceptualization, Data curation, Writing – review & editing

Affiliations Alcyone Therapeutics, Lowell, MA, United States of America, Voyager Therapeutics, Cambridge, MA, United States of America

Jillynne R. Zeller

Roles Data curation, Writing – review & editing

Affiliation Northern Biomedical Research, Spring Lake, MI, United States of America

Bryn A. Martin

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

brynm@uidaho.edu

Affiliations Department of Chemical and Biological Engineering, University of Idaho, Moscow, ID, United States of America, Alcyone Therapeutics, Lowell, MA, United States of America

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: This study was funded in part by Voyager Therapeutics. Authors BAM and GRS are employed by Alcyone Therapeutics. GRS was employed by Voyager Therapeutics during the course of this study. JRZ is a fulltime employee of Northern Biomedical. BAM has received grant support from Voyager Therapeutics, Genentech, Alcyone Lifesciences, Biogen, and Minnetronix; BAM is a member of the Neurapheresis Research Consortium. BAM is scientific advisory board member for Alcyone Lifesciences, Chiari and Syringomyelia Foundation, The International Society for Hydrocephalus and CSF Disorders, The International CSF Dynamics Society, and has served as a consultant to Voyager Therapeutics, Praxis Medicines, Roche, SwanBio Therapeutics, CereVasc, Minnetronix, Invicro, Genentech, Medtrad Biosystems, Behavior Imaging, Neurosyntek, and Cerebral Therapeutics. There are no patents, products in development or marketed products to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials.