About the Authors

Lauren Brady

Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Histopathology and Morbid Anatomy, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland

Brian Hayes

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliations Department of Histopathology, Cork University Hospital, Cork, Ireland, Department of Pathology, University College Cork, Cork, Ireland

Gráinne Sheill

Roles Investigation, Methodology, Writing – review & editing

Affiliation Discipline of Physiotherapy, School of Medicine, Trinity College Dublin, Dublin, Ireland

Anne-Marie Baird

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Histopathology and Morbid Anatomy, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland

Emer Guinan

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliation School of Medicine, Trinity College Dublin, Dublin, Ireland

Bryan Stanfill

Roles Formal analysis, Writing – review & editing

Affiliation Pacific Northwest National Laboratory, Richland, Washington, United States of America

Tatjana Vlajnic

Roles Investigation, Methodology, Writing – review & editing

Affiliation Institute of Pathology, University Hospital Basel, Basel, Switzerland

Orla Casey

Roles Investigation, Methodology, Writing – review & editing

Affiliation Cancer Trials Ireland, Dublin, Ireland

Verena Murphy

Roles Investigation, Methodology, Writing – review & editing

Affiliation Cancer Trials Ireland, Dublin, Ireland

John Greene

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Histopathology and Morbid Anatomy, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland

Emma H. Allott

Roles Formal analysis, Writing – review & editing

Affiliations Department of Histopathology and Morbid Anatomy, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland, Centre for Cancer Research and Cell Biology, Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom

Juliette Hussey

Roles Conceptualization, Writing – review & editing

Affiliation Discipline of Physiotherapy, School of Medicine, Trinity College Dublin, Dublin, Ireland

Fidelma Cahill

Roles Investigation, Methodology, Writing – review & editing

Affiliation King’s College London, School of Cancer and Pharmaceutical Sciences, Translational Oncology and Urology (TOUR), London, United Kingdom

Mieke Van Hemelrijck

Roles Investigation, Methodology, Writing – review & editing

Affiliation King’s College London, School of Cancer and Pharmaceutical Sciences, Translational Oncology and Urology (TOUR), London, United Kingdom

Nicola Peat

Roles Investigation, Methodology, Writing – review & editing

Affiliation Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom

Lorelei Mucci

Roles Conceptualization, Writing – review & editing

Affiliation Harvard T.H. Chan school of Public Health, Boston, Massachusetts, United States of America

Moya Cunningham

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Radiation Oncology, St Luke’s Hospital, Dublin, Ireland

Liam Grogan

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Oncology, Beaumont Hospital, Dublin, Ireland

Thomas Lynch

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Urology, St James’s Hospital, Dublin, Ireland

Rustom P. Manecksha

Roles Investigation, Methodology, Writing – review & editing

Affiliations Department of Urology, St James’s Hospital, Dublin, Ireland, Department of Surgery, Trinity College Dublin, Dublin, Ireland

John McCaffrey

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Oncology, Mater Misericordiae Hospital, Dublin, Ireland

Dearbhaile O’Donnell

Roles Investigation, Methodology, Writing – review & editing

Affiliation HOPE Directorate, St James’s Hospital, Dublin, Ireland

Orla Sheils

Roles Conceptualization, Writing – review & editing

Affiliation Department of Histopathology and Morbid Anatomy, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland

John O’Leary

Roles Conceptualization, Writing – review & editing

Affiliation Department of Histopathology, St James’s Hospital, Dublin, Ireland

Sarah Rudman

Roles Investigation, Methodology, Writing – review & editing

Affiliation Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom

Ray McDermott

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Oncology, Tallaght University Hospital, Dublin, Ireland

Stephen Finn

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

stephen.finn@tcd.ie

Affiliations Department of Histopathology and Morbid Anatomy, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland, Cancer Trials Ireland, Dublin, Ireland, Department of Histopathology, St James’s Hospital, Dublin, Ireland

Competing Interests

All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare: support from the World Cancer Research fund. AMB declares board membership of LUCE which has received support from Abbvie, Amgen, BMS, BI, Lilly, Merck, MSD, Novartis, Pfizer, Roche and Takeda, advisory boards for BMS, Takeda and Pfizer and personal fees and non-financial support from Roche, personal fees and non-financial support from MSD, outside the submitted work. BS reports funding from Trinity College Dublin throughout the conduct of this study. EG and MVH report membership of the editorial board of BMC Cancer. RMD reports personal fees from Clovis, grants and personal fees from Pfizer, grants from Amgen, personal fees and other from Bristol Myers Squibb, other from Merck, Bayer and Janssen and grants from Celgene outside the submitted work. SF reports personal fees and non-financial support from Pfizer, grants, personal fees and non-financial support from MSD, personal fees and non-financial support from Roche, grants, personal fees and non-financial support from Astellas, outside the submitted work. This does not alter our adherence to PLOS ONE policies on sharing data and materials.