About the Authors

Jianzhong Lu

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Hough Ear Institute, Oklahoma City, Oklahoma, United States of America

Matthew B. West

Roles Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Hough Ear Institute, Oklahoma City, Oklahoma, United States of America

Xiaoping Du

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft

Affiliation Hough Ear Institute, Oklahoma City, Oklahoma, United States of America

Qunfeng Cai

Roles Formal analysis, Investigation, Methodology

Affiliation Hough Ear Institute, Oklahoma City, Oklahoma, United States of America

Donald L. Ewert

Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision

Affiliation Hough Ear Institute, Oklahoma City, Oklahoma, United States of America

Weihua Cheng

Roles Formal analysis

Affiliation Hough Ear Institute, Oklahoma City, Oklahoma, United States of America

Don Nakmali

Roles Formal analysis, Investigation, Methodology

Affiliation Hough Ear Institute, Oklahoma City, Oklahoma, United States of America

Wei Li

Roles Data curation, Investigation

Affiliation Hough Ear Institute, Oklahoma City, Oklahoma, United States of America

Xiangping Huang

Roles Data curation, Formal analysis, Investigation

Affiliation Hough Ear Institute, Oklahoma City, Oklahoma, United States of America

Richard D. Kopke

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

rkopke@houghear.org

Affiliations Hough Ear Institute, Oklahoma City, Oklahoma, United States of America, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Departments of Physiology and Otolaryngology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

Competing Interests

The authors have read the journal’s policy, and the authors of this manuscript have the following competing interests to declare: RDK is a minor stockholder in Otologic Pharmaceutics Inc. The authors would like to declare the following patents/patent applications associated with this research: Patent families 10,555,915; 9,289,404; 10,111,843. The authors also declare the following product in development associated with this research: an oral combination drug (NAC plus HPN-07) being developed for prevention and/or treatment of acute sensorineural hearing loss. This does not alter our adherence to PLOS ONE policies on sharing data and materials.