https://orcid.org/0000-0001-5569-7261
About the Authors
- Keirnan Willett
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Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliation Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
- Reas S. Khan
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Roles Formal analysis, Investigation, Methodology
Affiliation Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
- Kimberly Dine
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Roles Data curation, Investigation
Affiliation Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
- Howard Wessel
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Roles Investigation, Writing – review & editing
Affiliation Noveome Biotherapeutics, Inc., Pittsburgh, Pennsylvania, United States of America
- Ziv Z. Kirshner
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Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing
Affiliation Noveome Biotherapeutics, Inc., Pittsburgh, Pennsylvania, United States of America
- Jodie L. Sauer
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Roles Investigation
Affiliation Noveome Biotherapeutics, Inc., Pittsburgh, Pennsylvania, United States of America
- Ashley Ellis
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Roles Investigation
Affiliation Noveome Biotherapeutics, Inc., Pittsburgh, Pennsylvania, United States of America
- Larry R. Brown
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Roles Writing – review & editing
Affiliation Noveome Biotherapeutics, Inc., Pittsburgh, Pennsylvania, United States of America
- Kenneth S. Shindler
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Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: Kenneth.Shindler@uphs.upenn.edu
Affiliation Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Competing Interests
The ST266 therapy studied here is proprietary property of Noveome Biotherapeutics, Inc. I, Kenneth Shindler, corresponding author for this manuscript, have previously received honoraria from and served on Scientific Advisory Boards from Noveome, and have received sponsored research funding from Noveome for other projects in the past, with no current funding. For the in vivo studies described in the current manuscript, Noveome provided ST266 to my lab at no cost, but funding for all other study materials and personnel was provided by grants from NIH and non-profit foundations. The manuscript does also include in vitro cell assay data from experiments performed by our collaborators at Noveome. Co-authors (HW, ZK, JS, AE, LB) from Noveome were involved in design and completion of the in vitro studies, but all in vivo studies on optic neuritis, which represent the majority of experiments in this manuscript, were designed and conducted without influence from any of the Noveome employees to reduce any potential conflicts of interest. Neither I, nor any of my lab members (coauthors KW, RK, KD), have any financial stake in Noveome or ST266. These competing interests do not alter our adherence to PLOS ONE policies on sharing data and materials.