Citric acid promoted melanin synthesis in B16F10 mouse melanoma cells, but inhibited it in human epidermal melanocytes and HMV-II melanoma cells via the GSK3β/β-catenin signaling pathway

Siqi Zhou; Kazuichi Sakamoto

doi:10.1371/journal.pone.0243565

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Open Access

Peer-reviewed

Research Article

Citric acid promoted melanin synthesis in B16F10 mouse melanoma cells, but inhibited it in human epidermal melanocytes and HMV-II melanoma cells via the GSK3β/β-catenin signaling pathway

Siqi Zhou,

Roles Investigation, Methodology, Writing – original draft

Affiliation Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

https://orcid.org/0000-0002-5024-7269

⨯
Kazuichi Sakamoto

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: sakamoto@biol.tsukuba.ac.jp

Affiliation Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

https://orcid.org/0000-0002-3826-0444

⨯

Citric acid promoted melanin synthesis in B16F10 mouse melanoma cells, but inhibited it in human epidermal melanocytes and HMV-II melanoma cells via the GSK3β/β-catenin signaling pathway

Siqi Zhou,
Kazuichi Sakamoto

Published: December 17, 2020
https://doi.org/10.1371/journal.pone.0243565

About the Authors

Siqi Zhou

Roles Investigation, Methodology, Writing – original draft

Affiliation Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

https://orcid.org/0000-0002-5024-7269

Kazuichi Sakamoto

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: sakamoto@biol.tsukuba.ac.jp

Affiliation Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

https://orcid.org/0000-0002-3826-0444

Competing Interests

The authors have declared that no competing interests exist.

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Citric acid
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Melanin
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Melanoma cells
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Melanocytes
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Phosphorylation
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Enzyme regulation
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Cancers and neoplasms
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Wnt signaling cascade
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