About the Authors

Michael Lenz

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

michael.l.lenz@gmail.com

Affiliations Institute of Organismic and Molecular Evolution, Johannes Gutenberg University Mainz, Mainz, Germany, Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

Andreas Schulz

Roles Investigation, Methodology, Writing – review & editing

Affiliation Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

Thomas Koeck

Roles Data curation, Investigation, Writing – review & editing

Affiliations Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main, Mainz, Germany

Steffen Rapp

Roles Investigation, Writing – review & editing

Affiliations Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main, Mainz, Germany

Markus Nagler

Roles Investigation, Writing – review & editing

Affiliation Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

Madeleine Sauer

Roles Investigation, Writing – review & editing

Affiliation Disease Genomics, Bayer AG, Wuppertal, Germany

Lisa Eggebrecht

Roles Investigation, Writing – review & editing

Affiliations Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

Vincent Ten Cate

Roles Investigation, Writing – review & editing

Affiliations Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

Marina Panova-Noeva

Roles Investigation, Writing – review & editing

Affiliations Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main, Mainz, Germany, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

Jürgen H. Prochaska

Roles Investigation, Writing – review & editing

Affiliations Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main, Mainz, Germany, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

Karl J. Lackner

Roles Investigation, Resources, Writing – review & editing

Affiliation Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

Thomas Münzel

Roles Funding acquisition, Resources, Writing – review & editing

Affiliations German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main, Mainz, Germany, Center for Cardiology, Cardiology I, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

Kirsten Leineweber

Roles Conceptualization, Investigation, Writing – review & editing

Affiliation Disease Genomics, Bayer AG, Wuppertal, Germany

Philipp S. Wild

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft

‡ These authors share last authorship on this work.

Affiliations Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main, Mainz, Germany, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

Miguel A. Andrade-Navarro

Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – original draft

‡ These authors share last authorship on this work.

Affiliation Institute of Organismic and Molecular Evolution, Johannes Gutenberg University Mainz, Mainz, Germany

Competing Interests

Michael Lenz, Andreas Schulz, Thomas Koeck, Steffen Rapp, Markus Nagler, Lisa Eggebrecht, Vincent Ten Cate, Karl J. Lackner, Thomas Münzel and Miguel A. Andrade-Navarro declare no conflict of interest. Madeleine Sauer and Kirsten Leineweber are employees of Bayer AG. Marina Panova-Noeva, Jürgen H. Prochaska, and Philipp S. Wild received funding from the Center for Thrombosis and Hemostasis Mainz. Philipp S. Wild reports grants from Bayer AG and from the German Federal Ministry of Education and Research, during the conduct of the study; grants and personal fees from Boehringer Ingelheim, grants from Philips Medical Systems, grants and personal fees from Sanofi-Aventis, grants and personal fees from Bayer Vital, grants from Daiichi Sankyo Europe, personal fees from Bayer Health Care, personal fees from Astra Zeneca, personal fees and non-financial support from Diasorin and non-financial support from I.E.M., outside the submitted work. This does not alter our adherence to PLOS ONE policies on sharing data and materials.