Perturbation of the human gastrointestinal tract microbial ecosystem by oral drugs to treat chronic disease results in a spectrum of individual specific patterns of extinction and persistence of dominant microbial strains

Hyunmin Koo; Casey D. Morrow

doi:10.1371/journal.pone.0242021

Loading metrics

Open Access

Peer-reviewed

Research Article

Perturbation of the human gastrointestinal tract microbial ecosystem by oral drugs to treat chronic disease results in a spectrum of individual specific patterns of extinction and persistence of dominant microbial strains

Hyunmin Koo ,

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

* E-mail: khmkhm87@uab.edu (HK); caseym@uab.edu (CDM)

Affiliation Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

https://orcid.org/0000-0001-6630-2165

⨯
Casey D. Morrow

Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

* E-mail: khmkhm87@uab.edu (HK); caseym@uab.edu (CDM)

Affiliation Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯

Perturbation of the human gastrointestinal tract microbial ecosystem by oral drugs to treat chronic disease results in a spectrum of individual specific patterns of extinction and persistence of dominant microbial strains

Hyunmin Koo,
Casey D. Morrow

Published: December 1, 2020
https://doi.org/10.1371/journal.pone.0242021

About the Authors

Hyunmin Koo

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

* E-mail: khmkhm87@uab.edu (HK); caseym@uab.edu (CDM)

Affiliation Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

https://orcid.org/0000-0001-6630-2165

Casey D. Morrow

Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

* E-mail: khmkhm87@uab.edu (HK); caseym@uab.edu (CDM)

Affiliation Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Bacteroides
Is the Subject Area "Bacteroides" applicable to this article?

Thanks for your feedback.
Diarrhea
Is the Subject Area "Diarrhea" applicable to this article?

Thanks for your feedback.
Drug therapy
Is the Subject Area "Drug therapy" applicable to this article?

Thanks for your feedback.
Microbial ecosystems
Is the Subject Area "Microbial ecosystems" applicable to this article?

Thanks for your feedback.
Eubacterium
Is the Subject Area "Eubacterium" applicable to this article?

Thanks for your feedback.
Metagenomics
Is the Subject Area "Metagenomics" applicable to this article?

Thanks for your feedback.
Shotgun sequencing
Is the Subject Area "Shotgun sequencing" applicable to this article?

Thanks for your feedback.
Oral diseases
Is the Subject Area "Oral diseases" applicable to this article?

Thanks for your feedback.