About the Authors

Logan Tillery

Contributed equally to this work with: Logan Tillery, Kayleigh Barrett

Roles Formal analysis, Investigation, Writing – original draft

Affiliations Department of Medicine, Division Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Disease (CERID) University of Washington, Seattle, Washington, United States of America, Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America

Kayleigh Barrett

Contributed equally to this work with: Logan Tillery, Kayleigh Barrett

Roles Formal analysis, Investigation, Writing – original draft

Affiliations Department of Medicine, Division Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Disease (CERID) University of Washington, Seattle, Washington, United States of America, Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America

Jenna Goldstein

Roles Writing – original draft

‡ JG, JWL, BO, NLT, LX and RMY also contributed equally to this work.

Affiliation Department of Biology, Washington University, St. Louis, Missouri, United States of America

Jared W. Lassner

Roles Writing – original draft

‡ JG, JWL, BO, NLT, LX and RMY also contributed equally to this work.

Affiliation Department of Biology, Washington University, St. Louis, Missouri, United States of America

Bram Osterhout

Roles Writing – original draft

‡ JG, JWL, BO, NLT, LX and RMY also contributed equally to this work.

Affiliation Department of Biology, Washington University, St. Louis, Missouri, United States of America

Nathan L. Tran

Roles Writing – original draft

‡ JG, JWL, BO, NLT, LX and RMY also contributed equally to this work.

Affiliation Department of Biology, Washington University, St. Louis, Missouri, United States of America

Lily Xu

Roles Writing – original draft

‡ JG, JWL, BO, NLT, LX and RMY also contributed equally to this work.

Affiliation Department of Biology, Washington University, St. Louis, Missouri, United States of America

Ryan M. Young

Roles Writing – original draft

‡ JG, JWL, BO, NLT, LX and RMY also contributed equally to this work.

Affiliation Department of Biology, Washington University, St. Louis, Missouri, United States of America

Justin Craig

Roles Investigation, Writing – original draft

Affiliations Department of Medicine, Division Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Disease (CERID) University of Washington, Seattle, Washington, United States of America, Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America

Ian Chun

Roles Investigation

Affiliations Department of Medicine, Division Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Disease (CERID) University of Washington, Seattle, Washington, United States of America, Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America

David M. Dranow

Roles Data curation, Investigation, Writing – review & editing

Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, UCB Pharma, Bainbridge Island, Washington, United States of America

Jan Abendroth

Roles Data curation, Investigation, Writing – review & editing

Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, UCB Pharma, Bainbridge Island, Washington, United States of America

Silvia L. Delker

Roles Data curation, Investigation

Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, UCB Pharma, Bainbridge Island, Washington, United States of America

Douglas R. Davies

Roles Data curation, Investigation

Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, UCB Pharma, Bainbridge Island, Washington, United States of America

Stephen J. Mayclin

Roles Data curation, Investigation

Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, UCB Pharma, Bainbridge Island, Washington, United States of America

Brandy Calhoun

Roles Data curation, Investigation

Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, UCB Pharma, Bainbridge Island, Washington, United States of America

Madison J. Bolejack

Roles Data curation, Investigation

Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, UCB Pharma, Bainbridge Island, Washington, United States of America

Bart Staker

Roles Writing – review & editing

Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, Seattle Children’s Research Institute, Seattle, Washington, United States of America

Sandhya Subramanian

Roles Investigation, Writing – review & editing

Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, Seattle Children’s Research Institute, Seattle, Washington, United States of America

Isabelle Phan

Roles Investigation, Writing – review & editing

Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, Seattle Children’s Research Institute, Seattle, Washington, United States of America

Donald D. Lorimer

Roles Data curation, Investigation, Writing – review & editing

Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, UCB Pharma, Bainbridge Island, Washington, United States of America

Peter J. Myler

Roles Writing – review & editing

Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, Seattle Children’s Research Institute, Seattle, Washington, United States of America, Department of Pediatrics, University of Washington, Seattle, Washington, United States of America, Department of Biomedical Informatics & Medical Education, University of Washington, Seattle, Washington, United States of America, Department of Global Health (Pathobiology), University of Washington, Seattle, Washington, United States of America

Thomas E. Edwards

Roles Writing – review & editing

Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, UCB Pharma, Bainbridge Island, Washington, United States of America

Dennis E. Kyle

Roles Investigation, Writing – review & editing

Affiliation Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

Christopher A. Rice

Roles Investigation, Writing – review & editing

Current address: Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia, United States of America

Affiliation Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

James C. Morris

Roles Investigation, Writing – review & editing

Affiliation Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America

James W. Leahy

Roles Investigation, Writing – review & editing

Affiliation Department of Chemistry, University of South Florida, Tampa, Florida, United States of America

Roman Manetsch

Roles Investigation, Writing – review & editing

Affiliation Department of Chemistry and Chemical Biology and Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts, United States of America

Lynn K. Barrett

Roles Project administration, Writing – original draft

Affiliations Department of Medicine, Division Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Disease (CERID) University of Washington, Seattle, Washington, United States of America, Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America

Craig L. Smith

Roles Investigation, Writing – original draft

Affiliation Department of Biology, Washington University, St. Louis, Missouri, United States of America

Wesley C. Van Voorhis

Roles Formal analysis, Writing – original draft

wesley@u.washington.edu

Affiliations Department of Medicine, Division Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Disease (CERID) University of Washington, Seattle, Washington, United States of America, Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, Department of Global Health (Pathobiology), University of Washington, Seattle, Washington, United States of America

Competing Interests

The authors have read the journal’s policy and have the following competing interests: DMD, JA, SLD, DRD, SJM, BC, MJB, DDL, and TEE are employees of UCB Pharma. The LS-CAT Sector 21 was supported by a grant from the Michigan Economic Development Corporation. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products associated with this research to declare.