About the Authors

George Gilles

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

Affiliation Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

Andrew D. McCulloch

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliations Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America, Department of Medicine, University of California San Diego, La Jolla, California, United States of America

Cord H. Brakebusch

Roles Conceptualization, Resources, Supervision, Writing – review & editing

Affiliation Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark

Kate M. Herum

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

kate.herum@bric.ku.dk

Affiliation Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark

Competing Interests

A.D.M. is a co-founder of and has an equity interest in Insilicomed Inc. and an equity interest in Vektor Medical, Inc. He serves on the scientific advisory board of Insilicomed, and as scientific advisor to both companies. Some of his research grants have been identified for conflict of interest management based on the overall scope of the project and its potential benefit to these companies. The author is required to disclose this relationship in publications acknowledging the grant support; however, the research subject and findings reported in this study did not involve the companies in any way and have no relationship with the business activities or scientific interests of either company. The terms of this arrangement have been reviewed and approved by the University of California San Diego in accordance with its conflict of interest policies. We declare that the competing interest statements by A.D.M. does not alter our adherence to PLOS ONE policies on sharing data and materials.