About the Authors

Masahiro Nakamori

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan, Department of Neurology, Suiseikai Kajikawa Hospital, Hiroshima, Japan

Naohisa Hosomi

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

nhosomi@hiroshima-u.ac.jp

Affiliations Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan, Department of Neurology, Chikamori Hospital, Kochi, Japan, Department of Disease Model, Research Institute of Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan

Hiromi Nishi

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of General Dentistry, Hiroshima University Hospital, Hiroshima, Japan

Shiro Aoki

Roles Conceptualization, Data curation, Methodology, Writing – original draft

Affiliation Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

Tomohisa Nezu

Roles Conceptualization, Data curation, Methodology

Affiliation Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

Yuji Shiga

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

Naoto Kinoshita

Roles Conceptualization, Investigation

Affiliation Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

Kenichi Ishikawa

Roles Investigation, Methodology

Affiliations Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan, Department of Neurology, Suiseikai Kajikawa Hospital, Hiroshima, Japan

Eiji Imamura

Roles Investigation, Methodology

Affiliation Department of Neurology, Suiseikai Kajikawa Hospital, Hiroshima, Japan

Tomoaki Shintani

Roles Investigation, Methodology

Affiliation Center of Oral Examination, Hiroshima University Hospital, Hiroshima, Japan

Hiroki Ohge

Roles Investigation, Methodology, Supervision, Validation

Affiliation Department of Infectious Diseases, Hiroshima University Hospital, Hiroshima, Japan

Hiroyuki Kawaguchi

Roles Conceptualization, Supervision, Validation

Affiliation Department of General Dentistry, Hiroshima University Hospital, Hiroshima, Japan

Hidemi Kurihara

Roles Conceptualization, Supervision

Affiliation Department of Periodontal Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

Shinichi Wakabayashi

Roles Investigation, Supervision, Writing – review & editing

Affiliation Department of Neurosurgery, Suiseikai Kajikawa Hospital, Hiroshima, Japan

Hirofumi Maruyama

Roles Conceptualization, Supervision, Validation, Writing – review & editing

Affiliation Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

Competing Interests

Hirofumi Maruyama reports research support from Eisai, Pfizer, Takeda Pharmaceutical, Otsuka Pharmaceutical, Nihon Pharmaceutical, Shionogi, Teijin Pharma, Fuji Film, Boehringer Ingelheim, Sumitomo Dainippon Pharma, Nihon Medi-Physics, Bayer, MSD, Daiichi Sankyo, Kyowa Hakko Kirin, Sanofi, Novartis, Kowa Pharmaceutical, Astellas Pharma, Tsumura, Japan Blood Products Organization, Mitsubishi Tanabe Pharma, and Mylan which are unrelated to the submitted work. This does not alter our adherence to PLOS ONE policies on sharing data and materials. All other authors declare that they have no conflicts of interest.