About the Authors
- Yuji Mizokami
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Roles Data curation, Formal analysis, Supervision, Writing – original draft, Writing – review & editing
Affiliation Department of Gastroenterology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan
- Takatsugu Yamamoto
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Roles Data curation, Writing – original draft, Writing – review & editing
* E-mail: ymmt@med.teikyo-u.ac.jp
Affiliation Department of Medicine, Teikyo University, Itabashi City, Tokyo, Japan
- Hirotsugu Atarashi
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Roles Data curation, Writing – original draft, Writing – review & editing
Affiliation Minami Hachioji Hospital, Hachioji, Tokyo, Japan
- Takeshi Yamashita
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Roles Conceptualization, Writing – review & editing
Affiliation The Cardiovascular Research Institute, Minato City, Tokyo, Japan
- Masaharu Akao
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Roles Conceptualization, Writing – review & editing
Affiliation National Hospital Organization Kyoto Medical Center, Fushimi Ward, Kyoto, Japan
- Takanori Ikeda
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Roles Conceptualization, Writing – review & editing
Affiliation Toho University Omori Medical Center, Ota City, Tokyo, Japan
- Yukihiro Koretsune
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Roles Conceptualization, Writing – review & editing
Affiliation National Hospital Organization Osaka National Hospital, Chuo Ward, Osaka, Japan
- Ken Okumura
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Roles Conceptualization, Writing – review & editing
Affiliation Saiseikai Kumamoto Hospital, Minami Ward, Kumamoto, Japan
- Wataru Shimizu
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Roles Conceptualization, Writing – review & editing
Affiliation Nippon Medical School, Bunkyo City, Tokyo, Japan
- Hiroyuki Tsutsui
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Roles Conceptualization, Writing – review & editing
Affiliation Kyushu University, Higashi Ward, Fukuoka, Japan
- Kazunori Toyoda
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Roles Conceptualization, Writing – review & editing
Affiliation National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
- Atsushi Hirayama
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Roles Conceptualization, Writing – review & editing
Affiliation Osaka Police Hospital, Tennoji Ward, Osaka, Japan
- Masahiro Yasaka
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Roles Conceptualization, Writing – review & editing
Affiliation National Hospital Organization Kyushu Medical Center, Chuo Ward, Fukuoka, Japan
- Takenori Yamaguchi
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Roles Conceptualization, Writing – review & editing
Affiliation National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
- Satoshi Teramukai
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Roles Formal analysis, Writing – review & editing
Affiliation Kyoto Prefectural University of Medicine, Kamigyo Ward, Kyoto, Japan
- Tetsuya Kimura
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Roles Writing – original draft, Writing – review & editing
Affiliation Medical Science Department, Daiichi Sankyo Co., Ltd., Chuo City, Tokyo, Japan
- Jumpei Kaburagi
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Roles Writing – original draft, Writing – review & editing
Affiliation Medical Science Department, Daiichi Sankyo Co., Ltd., Chuo City, Tokyo, Japan
- Atsushi Takita
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Roles Writing – original draft, Writing – review & editing
Affiliation Biostatistics and Data Management Department, Daiichi Sankyo Co., Ltd., Shinagawa-ku, Tokyo, Japan
- Hiroshi Inoue
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Roles Conceptualization, Writing – review & editing
Affiliation Saiseikai Toyama Hospital, Toyama, Toyama, Japan
Competing Interests
The authors have read the journal’s policy and have the following potential competing interests: Tetsuya Kimura, Jumpei Kaburagi, and Atsushi Takita are paid employees of Daiichi Sankyo Co., Ltd., Tokyo, Japan. Yuji Mizokami received research funding from Daiichi Sankyo, and remuneration from Daiichi Sankyo. Takatsugu Yamamoto received remuneration from Nippon Boehringer Ingelheim, Bristol-Myers Squibb, Takeda Pharmaceutical, Otsuka Pharmaceutical, and AstraZeneca. Hirotsugu Atarashi received remuneration from Daiichi Sankyo. Takeshi Yamashita received research funding from Bristol-Myers Squibb, Bayer, and Daiichi Sankyo, manuscript fees from Daiichi Sankyo and Bristol-Myers Squibb, and remuneration from Daiichi Sankyo, Bayer, Pfizer Japan, and Bristol-Myers Squibb. Masaharu Akao received research funding from Bayer and Daiichi Sankyo, and remuneration from Bristol-Myers Squibb, Nippon Boehringer Ingelheim, Bayer, and Daiichi Sankyo. Takanori Ikeda received research funding from Daiichi Sankyo and Bayer, and remuneration from Daiichi Sankyo, Bayer, Nippon Boehringer Ingelheim, and Bristol-Myers Squibb. Yukihiro Koretsune received remuneration from Daiichi Sankyo, Bayer, and Nippon Boehringer Ingelheim. Ken Okumura received remuneration from Nippon Boehringer Ingelheim, Daiichi Sankyo, Johnson & Johnson, and Medtronic. Wataru Shimizu received research funding from Bristol-Myers Squibb, Daiichi Sankyo, and Nippon Boehringer Ingelheim, and patent royalties/licensing fees from Daiichi Sankyo, Pfizer Japan, Bristol-Myers Squibb, Bayer, and Nippon Boehringer Ingelheim. Hiroyuki Tsutsui received research funding from Daiichi Sankyo and Nippon Boehringer Ingelheim, remuneration from Daiichi Sankyo, Bayer, Nippon Boehringer Ingelheim, and Pfizer Japan, scholarship funding from Daiichi Sankyo, and consultancy fees from Pfizer Japan, Bayer, and Nippon Boehringer Ingelheim. Kazunori Toyoda received remuneration from Daiichi Sankyo, Bayer, Bristol-Myers Squibb, and Nippon Boehringer Ingelheim. Atsushi Hirayama participated in a course endowed by Boston Scientific Japan, and has received research funding from Daiichi Sankyo and Bayer, and remuneration from Bayer, Daiichi Sankyo, Bristol-Myers Squibb, and Nippon Boehringer Ingelheim. Masahiro Yasaka received research funding from Nippon Boehringer Ingelheim, and remuneration from Nippon Boehringer Ingelheim, Daiichi Sankyo, Bayer, Bristol-Myers Squibb, and Pfizer Japan. Takenori Yamaguchi acted as an Advisory Board member of Daiichi Sankyo and received remuneration from Daiichi Sankyo and Bristol-Myers Squibb. Satoshi Teramukai received research funding from Nippon Boehringer Ingelheim and remuneration from Daiichi Sankyo. Tetsuya Kimura, Jumpei Kaburagi, and Atsushi Takita are employees of Daiichi Sankyo. Hiroshi Inoue received remuneration from Daiichi Sankyo, Bayer, Bristol-Myers Squibb, and Nippon Boehringer Ingelheim. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The authors would like to declare the following patents/patent applications associated with this research: Daiichi Sankyo has launched Nexium® (esomeprazole magnesium hydrate) which is one of the proton pump inhibitors.