About the Authors

Yuji Mizokami

Roles Data curation, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Gastroenterology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan

Takatsugu Yamamoto

Roles Data curation, Writing – original draft, Writing – review & editing

ymmt@med.teikyo-u.ac.jp

Affiliation Department of Medicine, Teikyo University, Itabashi City, Tokyo, Japan

Hirotsugu Atarashi

Roles Data curation, Writing – original draft, Writing – review & editing

Affiliation Minami Hachioji Hospital, Hachioji, Tokyo, Japan

Takeshi Yamashita

Roles Conceptualization, Writing – review & editing

Affiliation The Cardiovascular Research Institute, Minato City, Tokyo, Japan

Masaharu Akao

Roles Conceptualization, Writing – review & editing

Affiliation National Hospital Organization Kyoto Medical Center, Fushimi Ward, Kyoto, Japan

Takanori Ikeda

Roles Conceptualization, Writing – review & editing

Affiliation Toho University Omori Medical Center, Ota City, Tokyo, Japan

Yukihiro Koretsune

Roles Conceptualization, Writing – review & editing

Affiliation National Hospital Organization Osaka National Hospital, Chuo Ward, Osaka, Japan

Ken Okumura

Roles Conceptualization, Writing – review & editing

Affiliation Saiseikai Kumamoto Hospital, Minami Ward, Kumamoto, Japan

Wataru Shimizu

Roles Conceptualization, Writing – review & editing

Affiliation Nippon Medical School, Bunkyo City, Tokyo, Japan

Hiroyuki Tsutsui

Roles Conceptualization, Writing – review & editing

Affiliation Kyushu University, Higashi Ward, Fukuoka, Japan

Kazunori Toyoda

Roles Conceptualization, Writing – review & editing

Affiliation National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

Atsushi Hirayama

Roles Conceptualization, Writing – review & editing

Affiliation Osaka Police Hospital, Tennoji Ward, Osaka, Japan

Masahiro Yasaka

Roles Conceptualization, Writing – review & editing

Affiliation National Hospital Organization Kyushu Medical Center, Chuo Ward, Fukuoka, Japan

Takenori Yamaguchi

Roles Conceptualization, Writing – review & editing

Affiliation National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

Satoshi Teramukai

Roles Formal analysis, Writing – review & editing

Affiliation Kyoto Prefectural University of Medicine, Kamigyo Ward, Kyoto, Japan

Tetsuya Kimura

Roles Writing – original draft, Writing – review & editing

Affiliation Medical Science Department, Daiichi Sankyo Co., Ltd., Chuo City, Tokyo, Japan

Jumpei Kaburagi

Roles Writing – original draft, Writing – review & editing

Affiliation Medical Science Department, Daiichi Sankyo Co., Ltd., Chuo City, Tokyo, Japan

Atsushi Takita

Roles Writing – original draft, Writing – review & editing

Affiliation Biostatistics and Data Management Department, Daiichi Sankyo Co., Ltd., Shinagawa-ku, Tokyo, Japan

Hiroshi Inoue

Roles Conceptualization, Writing – review & editing

Affiliation Saiseikai Toyama Hospital, Toyama, Toyama, Japan

Competing Interests

The authors have read the journal’s policy and have the following potential competing interests: Tetsuya Kimura, Jumpei Kaburagi, and Atsushi Takita are paid employees of Daiichi Sankyo Co., Ltd., Tokyo, Japan. Yuji Mizokami received research funding from Daiichi Sankyo, and remuneration from Daiichi Sankyo. Takatsugu Yamamoto received remuneration from Nippon Boehringer Ingelheim, Bristol-Myers Squibb, Takeda Pharmaceutical, Otsuka Pharmaceutical, and AstraZeneca. Hirotsugu Atarashi received remuneration from Daiichi Sankyo. Takeshi Yamashita received research funding from Bristol-Myers Squibb, Bayer, and Daiichi Sankyo, manuscript fees from Daiichi Sankyo and Bristol-Myers Squibb, and remuneration from Daiichi Sankyo, Bayer, Pfizer Japan, and Bristol-Myers Squibb. Masaharu Akao received research funding from Bayer and Daiichi Sankyo, and remuneration from Bristol-Myers Squibb, Nippon Boehringer Ingelheim, Bayer, and Daiichi Sankyo. Takanori Ikeda received research funding from Daiichi Sankyo and Bayer, and remuneration from Daiichi Sankyo, Bayer, Nippon Boehringer Ingelheim, and Bristol-Myers Squibb. Yukihiro Koretsune received remuneration from Daiichi Sankyo, Bayer, and Nippon Boehringer Ingelheim. Ken Okumura received remuneration from Nippon Boehringer Ingelheim, Daiichi Sankyo, Johnson & Johnson, and Medtronic. Wataru Shimizu received research funding from Bristol-Myers Squibb, Daiichi Sankyo, and Nippon Boehringer Ingelheim, and patent royalties/licensing fees from Daiichi Sankyo, Pfizer Japan, Bristol-Myers Squibb, Bayer, and Nippon Boehringer Ingelheim. Hiroyuki Tsutsui received research funding from Daiichi Sankyo and Nippon Boehringer Ingelheim, remuneration from Daiichi Sankyo, Bayer, Nippon Boehringer Ingelheim, and Pfizer Japan, scholarship funding from Daiichi Sankyo, and consultancy fees from Pfizer Japan, Bayer, and Nippon Boehringer Ingelheim. Kazunori Toyoda received remuneration from Daiichi Sankyo, Bayer, Bristol-Myers Squibb, and Nippon Boehringer Ingelheim. Atsushi Hirayama participated in a course endowed by Boston Scientific Japan, and has received research funding from Daiichi Sankyo and Bayer, and remuneration from Bayer, Daiichi Sankyo, Bristol-Myers Squibb, and Nippon Boehringer Ingelheim. Masahiro Yasaka received research funding from Nippon Boehringer Ingelheim, and remuneration from Nippon Boehringer Ingelheim, Daiichi Sankyo, Bayer, Bristol-Myers Squibb, and Pfizer Japan. Takenori Yamaguchi acted as an Advisory Board member of Daiichi Sankyo and received remuneration from Daiichi Sankyo and Bristol-Myers Squibb. Satoshi Teramukai received research funding from Nippon Boehringer Ingelheim and remuneration from Daiichi Sankyo. Tetsuya Kimura, Jumpei Kaburagi, and Atsushi Takita are employees of Daiichi Sankyo. Hiroshi Inoue received remuneration from Daiichi Sankyo, Bayer, Bristol-Myers Squibb, and Nippon Boehringer Ingelheim. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The authors would like to declare the following patents/patent applications associated with this research: Daiichi Sankyo has launched Nexium® (esomeprazole magnesium hydrate) which is one of the proton pump inhibitors.