About the Authors

Yohei Honda

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft

y.honda@po.nippon-shinyaku.co.jp

Affiliation Discovery Research Laboratories, Nippon Shinyaku Co., Ltd, Kyoto, Japan

Keiji Kosugi

Roles Conceptualization, Investigation, Methodology, Writing – original draft

Affiliation R&D Administration Division, Nippon Shinyaku Co., Ltd, Kyoto, Japan

Chiaki Fuchikami

Roles Formal analysis, Investigation

Affiliation Discovery Research Laboratories, Nippon Shinyaku Co., Ltd, Kyoto, Japan

Kazuya Kuramoto

Roles Formal analysis, Validation, Visualization, Writing – original draft

Affiliation R&D Administration Division, Nippon Shinyaku Co., Ltd, Kyoto, Japan

Yuki Numakura

Roles Formal analysis

Affiliation Discovery Research Laboratories, Nippon Shinyaku Co., Ltd, Kyoto, Japan

Keiichi Kuwano

Roles Conceptualization, Project administration, Supervision

Affiliation R&D Administration Division, Nippon Shinyaku Co., Ltd, Kyoto, Japan

Competing Interests

All authors are employed by Nippon Shinyaku Co., Ltd. The funders had no role in study design, data collection and analysis, or preparation of the manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials.