About the Authors

Katsutoshi Miyosawa

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan, Tokyo New Drug Research Laboratories, Kowa Company, Ltd., Tokyo, Japan

Hiroshi Iwata

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

hiroiwata-circ@umin.ac.jp

Affiliation Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Asuka Minami-Takano

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Hidemori Hayashi

Roles Investigation, Writing – review & editing

Affiliation Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Haruna Tabuchi

Roles Investigation, Writing – review & editing

Affiliation Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Gaku Sekita

Roles Investigation, Writing – review & editing

Affiliation Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Tomoyasu Kadoguchi

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Kai Ishii

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Yui Nozaki

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Takehiro Funamizu

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Yuichi Chikata

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Satoshi Matsushita

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Cardiovascular Surgery, Juntendo University Graduate School of Medicine, Tokyo, Japan

Atsushi Amano

Roles Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Surgery, Juntendo University Graduate School of Medicine, Tokyo, Japan

Masataka Sumiyoshi

Roles Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Juntendo University Nerima Hospital, Tokyo, Japan

Yuji Nakazato

Roles Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Juntendo University Urayasu Hospital, Chiba, Japan

Hiroyuki Daida

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Tohru Minamino

Roles Formal analysis, Supervision, Writing – review & editing

Affiliations Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan, Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development, Tokyo, Japan

Competing Interests

One of the authors [KM] received salary from the commercial company, Kowa Company, Ltd. The company did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials.